NKX2-1

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NKX2-1

A gene on chromosome 14q13 that encodes a transcription factor which binds and activates the promoter of thyroid-specific genes—e.g., for thyroglobulin, thyroperoxidase and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype, and it may play a role in lung development and surfactant homeostasis.
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miRNA miR function Regulation miR-16 p53, cell cycle, JAK/STAT signaling Down miR-21 Fatty acid synthesis, apoptosis miR-146a Inflammation, NF[kappa][beta] mediator miR-223 Immunology Up miR-129 Cell cycle regulation, apoptosis Down miR-634 Inflammation miR-340 Cell migration and invasion Up miR-365 Targets NKX2.
In models of lung adenocarcinoma, the researchers uncovered a set of elevated proteins that are regulated by the NKX2.