NKX2-3 | definition of NKX2-3 by Medical dictionary
NKX2-3 A gene on chromosome 10q24.2 that encodes a putative transcription factor of unknown function.
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References in periodicals archive
In addition to the reported disease-specific loci, UC and CD share some susceptibility genes, such as IR23, IL12B, NKX2-3
, and MST1.
The transcription factor NKX2-3
regulates the correct localization of lymphocytes and may further contribute to the immune response in intestinal tissue that induces IBD .
Because Bmp2/4 is not antagonized by Pinhead, it activates the regulatory genes specifically expressed in the ventral epidermis, including Nkx2-3
(formerly called Nk4), via autocrine signaling.