NKX2-2

NKX2-2

A gene on chromosome 20p11.22 that encodes a transcription activator required for maintaining NEUROD1 expression in the endocrine pancreas. NKX2-2 may be involved in specifying diencephalic neuromeric boundaries and controlling gene expression during axonal guidance. It associates with chromatin at the NEUROD1 promoter regions.
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Although the functional role of some famous transcription factors such as AR, SMAD3 and VDR are well known as genes linked to prostate cancer (40-42), the 9 transcription factors (CAMTA1, ISL1, MNX1, NHLH2, NKX2-2, STAT2, ZNF146, ZNF205, and ZNF529) are new candidates that may have critical roles in prostate cancer based on topological significance and regulatory changes during cancer progression.
NKX2-2 is a transcription factor with a crucial role in differentiation of the central nervous system and pancreatic islets, which has been demonstrated to be expressed in 93% of Ewing sarcomas/primitive neuroectodermal tumors and was not expressed in most of the other small round cell tumors, with exception of olfactory neuroblastomas and a minor subset of small cell carcinomas, synovial sarcomas, mesenchymal chondrosarcomas, and malignant melanomas.