NKX2-1


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NKX2-1

A gene on chromosome 14q13 that encodes a transcription factor which binds and activates the promoter of thyroid-specific genes—e.g., for thyroglobulin, thyroperoxidase and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype, and it may play a role in lung development and surfactant homeostasis.
References in periodicals archive ?
Gene (a) Symbol Description NKX2-1 (TTF-1) NK2 homeobox 1 (thyroid transcription factor 1) SFTA3 Surfactant associated 3 SFTA2 Surfactant associated 2 LMO3 LIM domain only 3 (rhombotin-like 2) XAGE1D X antigen family, member 1D CLDN3 Claudin 3 Median expression value (b) Symbol Adenocarcinoma Squamous cell carcinoma NKX2-1 (TTF-1) 2956.61025 82.2006 SFTA3 2412.19165 66.691 SFTA2 1951.85825 41.01335 LMO3 1901.15055 95.90595 XAGE1D 1873.0292 5.0326 CLDN3 1647.12575 93.83215 (a) All the genes conforming to the following two conditions are listed: (1) median expression value of the gene >1500 in adenocarcinoma and (2) median expression value of the gene <100 in squamous cell carcinoma.
Then they guided the embryonic stem cells through various stages while switching Nkx2-1 on and off for short periods of time and found there was one narrow timeframe where turning on this gene converted the majority of cells to thyroid cells.
Citation: Keri Dame et al., "Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1," Stem Cell Reports, February 2017 DOI: 10.1016/j.stemcr.2016.12.024
The specificity of RNAscope for both TTF-1 (NKX2-1) and napsin A was tested in a group of frequently [CK7.sup.+] carcinomas/ACAs from the breast, bladder, esophagus, pancreas, and ovary.
Kurotani et al., "CAATT/enhancerbinding proteins a and S interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression," The Journal of Biological Chemistry, vol.
In a minority of these patients, the congenital hypothyroidism is associated with mutations in genes responsible for the development or growth of thyroid follicular cells: thyroid transcription factor 1 (TTF-1; also known as TITF1, NKX2-1, or T/EBP) (3,4), thyroid transcription factor 2 (TTF-2; also known as TITF2, FOXE1, or FKHL15) (5), paired box transcription factor 8 (PAX-8) (6-9), thyrotropin [(TSH).sup.3] (10,11), and TSH receptor (12-14).
Among the most relevant genes identified (Table), ERBB2, ARNT, and NKX2-1 were described in a large-scale study of lung tumors by SNP array analysis.