IL12B

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IL12B

A gene on chromosome 5q31.1-q33.1 that encodes interleukin-12B, a cytokine which acts on T and natural killer cells and has a broad array of biological activities; it is expressed by activated macrophages and is an essential inducer of Th1 cell development. IL-12B maintains memory/effector Th1 cells at a level which confers long-term protection against intracellular pathogens. It associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.

Molecular pathology
IL12B overexpression is found in patients with multiple sclerosis; polymorphism of IL12B is associated with an increased risk of asthma in children.
References in periodicals archive ?
US First Republic Bank (NYSE:FRC) said it had purchased a 24.5% stake in local business management firm Nigro Karlin Segal & Feldstein LLC (NKSF), without providing financial details.
23 September 2013 a[euro]" US First Republic Bank (NYSE:FRC) said it had purchased a 24.5% stake in localA business management firm Nigro Karlin Segal & Feldstein LLC (NKSF), without providing financial details.
23 September 2013 - US First Republic Bank (NYSE:FRC) said it had purchased a 24.5% stake in local business management firm Nigro Karlin Segal & Feldstein LLC (NKSF), without providing financial details.