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Previous studies have shown that bumetanide (the NKCC1 inhibitor) can block neonatal propofol- or sevoflurane-induced seizure activity in rats, leading us to explore the effect of bumetanide on inhibitory transmission after neonatal propofol exposure.
Bumetanide, a selective NKCC1 antagonist, is used to treat seizures but is still controversial.
The cation-chloride cotransporter NKCC1 promotes sharp waves in the neonatal rat hippocampus.
Our pilot data indicate that AVP inhibits the Na-K-2Cl cotransporter NKCC1 and activates the K-Cl cotransporter KCC2 in a manner consistent with reduction of excitability.
The main goal of this project is to understand the mechanisms that some ion transporters, like the NKCC1 protein, use to increase cell migration, and how different factors, like chemoattractive substances affect this process.
Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia.
Prolonged interferon-exposure decreases ion transport, NKCC1, and Na+-K+-ATPase expression in human intestinal xenografts in vivo.
sup], NKCC1 is expressed in many cells, including endothelial cells, and plays an important role in regulating permeability.
sup] NKCC1 phosphorylation is decreased in the aorta of SPAK-deficient mice when compared with wild-type mice.
NKCC1 is a widely-distributed isoform found on the basolateral membrane of secretory tissues.
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