NKCC1

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Previous studies have shown that bumetanide (the NKCC1 inhibitor) can block neonatal propofol- or sevoflurane-induced seizure activity in rats, leading us to explore the effect of bumetanide on inhibitory transmission after neonatal propofol exposure.

Bumetanide, a selective NKCC1 antagonist, is used to treat seizures but is still controversial.

The cation-chloride cotransporter NKCC1 promotes sharp waves in the neonatal rat hippocampus.

Neonatal Propofol and Etomidate Exposure Enhance Inhibitory Synaptic Transmission in Hippocampal Cornus Ammonis 1 Pyramidal Neurons

Our pilot data indicate that AVP inhibits the Na-K-2Cl cotransporter NKCC1 and activates the K-Cl cotransporter KCC2 in a manner consistent with reduction of excitability.

PRESSBIRTH: Arginine vasopressin and ion transporters in the modulation of brain excitability during birth and birth asphyxia seizures

The main goal of this project is to understand the mechanisms that some ion transporters, like the NKCC1 protein, use to increase cell migration, and how different factors, like chemoattractive substances affect this process.

Dr. Alfredo Quinones: the brains behind brain cancer research

Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia.

Prenatal choline and the development of schizophrenia

Prolonged interferon-exposure decreases ion transport, NKCC1, and Na+-K+-ATPase expression in human intestinal xenografts in vivo.

Valoracion de parametros clinicos y lesiones en organos de cerdos durante el periodo posdestete

sup][3],[4] NKCC1 is expressed in many cells, including endothelial cells, and plays an important role in regulating permeability.

sup][13] NKCC1 phosphorylation is decreased in the aorta of SPAK-deficient mice when compared with wild-type mice.

Role of sterile 20/sps1-related proline/alanine-rich kinase in mice with endotoxic shock

NKCC1 is a widely-distributed isoform found on the basolateral membrane of secretory tissues.

Poster Session Biological; Earth; Education; Engineering; Environmental; Physical; Social 10:00 - 11:00am Kerns Chapel

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