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Bumetanide, an inhibitor of NKCC1 (Na-K-2Cl cotransporter isoform 1), enhances propofol-induced loss of righting reflex but not its immobilizing actions in neonatal rats.
Focus on "COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination".
floridae genome database (http://genome.jgi-psf.org//Brafl1/Brafl1.home.html) for the homologues of vertebrate NKA and NKCC (using NKA alpha 1 and NKCC1 as queries) revealed the presence of a single NKA (GenBank accession number: XP_002610679.1) and NKCC (GenBank accession number: XP_002609755.1), respectively.
For example, glial cells alter the expression of KCC2 and NKCC1, thereby decreasing GABAergic inhibitory tone and increasing glutamate release .
Rafiqi et al., "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1," The Biochemical Journal, vol.
Our pilot data indicate that AVP inhibits the Na-K-2Cl cotransporter NKCC1 and activates the K-Cl cotransporter KCC2 in a manner consistent with reduction of excitability.My laboratory has an internationally leading role in work on neuronal pH and Cl- regulation and on functions of the immature brain.
The main goal of this project is to understand the mechanisms that some ion transporters, like the NKCC1 protein, use to increase cell migration, and how different factors, like chemoattractive substances affect this process.
Anion ([Cl.sup.-)] secretion through the cystic fibrosis transmembrane conductance regulator (CFTR) or calcium-dependent chloride channels (CaCC) is enabled after building up a cytosolic anion potential, which results from the activation of basolateral transporters notably: the [Na.sup.+]/[K.sup.+]-ATPase maintaining the [K.sup.+] concentration gradient between the intracellular and the extracellular spaces; the [Ca.sup.2+]-dependent ([mathematical expression not reproducible]) and ATP- sensitive ([K.sub.ATP]) [K.sup.+] channels, responsible for the driving force allowing for uptake of Cl- via the basolateral [Na.sup.+]-[K.sup.+]-[Cl.sup.-] cotransporter type 1 (NKCC1).
The molecular mechanisms are well described in several species and include basolateral [Na.sup.+],[K.sup.+] -ATPase and [Na.sup.+],[K.sup.+],2[Cl.sup.-] cotransporter (NKCC1), apical cystic fibrosis transmembrane conductance regulator (CFTR), and cation leaky tight junctions between neighboring cells, which are structurally and functionally defined by various claudin isoforms.
Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia.
Prolonged interferon-exposure decreases ion transport, NKCC1, and Na+-K+-ATPase expression in human intestinal xenografts in vivo.
The basolateral [Na.sup.+]-[K.sup.+]-[2Cl.sup.-] co-transporter (NKCC1) is essential for secretion of fluid into the pulmonary airways.
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