NKX2-2

(redirected from NK2 homeobox 2)

NKX2-2

A gene on chromosome 20p11.22 that encodes a transcription activator required for maintaining NEUROD1 expression in the endocrine pancreas. NKX2-2 may be involved in specifying diencephalic neuromeric boundaries and controlling gene expression during axonal guidance. It associates with chromatin at the NEUROD1 promoter regions.