NKX2-1

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NKX2-1

A gene on chromosome 14q13 that encodes a transcription factor which binds and activates the promoter of thyroid-specific genes—e.g., for thyroglobulin, thyroperoxidase and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype, and it may play a role in lung development and surfactant homeostasis.
References in periodicals archive ?
Xu et al., "Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation," American Journal of Respiratory and Critical Care Medicine, vol.
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.
Campbell et al., "Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb," Respiratory Research, vol.
Additional expression of NK2 homeobox 1 (NKX2-1) and ISL LIM homeobox 1 (ISL1) is associated with the development of forebrain cholinergic neurons and coexpression of p75 receptor demonstrated the presence of BFCNs.