NK1


Also found in: Acronyms.

NK1

Abbreviation for neurokinin-1 antagonist.
References in periodicals archive ?
Mantyh, "Neurobiology of substance P and the NK1 receptor," The Journal of Clinical Psychiatry, vol.
NK1 receptor antagonists: Substance P is a neuropeptide which plays a major role in the induction and maintenance of pruritus.
The filing of the NDA for CINVANTI is an important milestone, bringing us one step closer to a new NK1 receptor antagonist treatment option for cancer patients suffering from the debilitating side effects of chemotherapy, said Kimberly J.
The shared conclusion from the reviewed reports is that SP is indeed an important mediator of pruritus in many diseases and that aprepitant exhibits antipruritic activity as a NK1 receptor and SP antagonist.
(19,20,22) By binding NK-1 receptors at the NTS rather than single pathway leading to the NTS, aprepitant is likely able to modulate and attenuate emetigogenic signals in the more "central" portion of the emesis pathway which may partially explain its increased efficacy in PONV prevention across a wide variety of emetogenic stimuli (23,24,25) There is also evidence of crosstalk between 5HT3 and NK1 receptor signaling pathways as stimulation of one receptor potentates the inward current of the other receptor in rat models.
Primary antibodies, anti-CD57 antigens (NK1, Novocastra, Leica Biosystems, Nussloch, Germany), anti-vimentin (V9, Invitrogen, Life Technologies, Carlsbad, CA, USA), anti-pancytokeratins (AE1/AE3, Dako, Glostrup, Denmark), anti-actin smooth muscle (1A4, Dako), antidesmin (D33, Dako), anti-S100 (polyclonal, Dako), anti-CD34 (QBEnd10, Cell Marque, Rocklin, CA, USA), anti-ki-67 (MIB-1/SP6, Dako), anti-Factor VIII (polyclonal, Dako), anti-macrophage (HAM56, Dako), and anti-CD31 (Jc70, Cell Marque), were diluted in 1% bovine serum albumin 0.1% Na3N on phosphate-buffered saline (pH 7.4), followed by overnight incubation (18 hours) at 4[degrees]C.
In the treatment NK0, N and K fertilizations were not applied; in NK1, 50% of the standard recommendation of N and K was applied (175 kg [ha.sup.-1] [year.sup.-1] of N and 285 kg [ha.sup.-1] [year.sup.-1] of [K.sub.2]O); in NK2, 100% of the standard recommendation of N and K was applied (350 kg [ha.sup.-1] [year.sup.-1] of N and 570 kg [ha.sup.-1] [year.sup.-1] of [K.sub.2]O) and, in NK3, 150% of the standard recommendation of N and K was applied (525 kg [ha.sup.-1] [year.sup.-1] of N and 855 kg [ha.sup.-1] [year.sup.-1] of [K.sub.2]O).
A partir de esta solucion madre se calcularon las diferentes relaciones N/K, de tal manera que para la solucion NK1 corresponden (mMol x [l.sup.-1]) 23,25 N[O.sub.3.sup.-] y 5,99 [K.sup.+]; para NK2: 15,00 N[O.sub.3.sup.-] y 5,99 [K.sup.+]; para NK3: 15,00 N[O.sub.3.sup.-] y 8,14 [K.sup.+]; y para NK4: 10,00 N[O.sub.3.sup.-] y 6,60 [K.sup.+].
Akynzeo targets two critical signaling pathways associated with CINV by combining netupitant, an NK1 receptor antagonist, and palonosetron, a 5-HT3 receptor antagonist, in a single capsule for the prevention of CINV.
Ademas, estas celulas iNKT poseen marcadores caracteristicos de celulas asesinas naturales (NK), como el receptor NK1.1, y un fenotipo similar al de las celulas T de memoria efectora, expresando altos niveles de CD44 y CD69, ademas de una baja expresion de CD62L (2).
Methyl mercury exposure via placenta and milk impairs natural killer (NK1 cell function in newborn rats.
Other differences between NKT and conventional T cells have since been recognized; NKT cells belong to either DN or [CD4.sup.+] populations, express CD69, [CD5.sup.high], CD44 and NK1.1, are present in the thymus, liver, spleen and BM, and produce both Th1 and Th2 cytokines.