NK1


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NK1

Abbreviation for neurokinin-1 antagonist.
References in periodicals archive ?
Is the addition of an NK1 receptor antagonist beneficial in patients receiving carboplatin?
The VLY-686, NK1 antagonist, Phase 2 study in chronic pruritus is ongoing and results are expected in mid-2015.
Netupitant, a highly selective NK1 receptor antagonist, is thought to work by blocking the action of substance P, an endogenous neurotransmitter contained in high concentrations in the vomiting center of the brainstem that can stimulate the vomiting reflex.
Key classes of mechanism of action include acetylcholine inhibitors, 3-adrenergic receptor agonists, anticholinergics, TRPV1 antagonists, alpha-agonists, cell therapies, desmopressin formulations, EP 1 receptor antagonists, opioid receptor agonists, vanilloid receptor agonists, delta receptor agonists and NK1 antagonists.
Birch PJ, Harrison SM, Hayes AG, Rogers H, Tyers MB (1992) The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345, produces antinociceptive and anti-oedema effects in the rat.
Kluberfood NK1 Z 8-001 Spray is a cleaner-degreasing spray, formulated to aid in the rapid and thorough removal of oils, greases, waxes and resin residues.
Palframan RT, Costa SK, Wilsoncroft P, Antunes E, De Nucci G, Brain SD (1996) The effect of tachykinin NK1 receptor antagonist SR 140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider.
Netupitant is a highly selective NK1 receptor antagonist, an antiemetic that works by blocking the action of Substance P, an endogenous neurotransmitter contained in high concentrations in the vomiting center of the brainstem that can stimulate the vomiting reflex.
In the current study, SRI researchers used two chemical markers-one on the outside of brain cells called NK1 and the other on the inside of the cell called nNOS-to investigate the activity of the sleep-active neurons in more detail.
Animal and human Positron Emission Tomography (PET) studies with aprepitant have shown that it crosses the blood brain barrier and occupies brain NK1 receptors.
The key classes of mechanism of action include acetylcholine antagonists/blockers, muscarinic receptor antagonists, beta-3 adrenoceptor antagonists, calcium influx inhibitors and intracellular calcium modulators, nonpeptide d-receptor agonists, neuronal serotonin and norepinephrine reuptake inhibitors, vanilloid receptor agonists, beta-3 adrenergic receptor agonists, noradrenaline reuptake inhibitors and NK1 receptor antagonists.