HCAR2

(redirected from NIACR1)

HCAR2

A gene on chromosome 12q24.31 that encodes a G protein-coupled receptor. HCAR2 is a high-affinity receptor for nicotinic acid/niacin and for beta-hydroxybutyrate; it increases adiponectin secretion and reduces lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase.
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References in periodicals archive ?
Gpr109A (encoded by Niacr1) is a receptor for butyrate and niacin in the colon.
found that SCFA butyrate suppressed colonic stem cell proliferation [112], perhaps through receptors encoded by Ffar3, Ffar2, and Niacr1 [113].
The therapeutic effects of niacin are primarily mediated through G protein--coupled receptors not screened in ToxCast[TM], niacin receptor 1 (NIACR1) and niacin receptor 2 (NIACR2).