amino-terminal

(redirected from NH2-terminal)

a·mi·no-ter·mi·nal

(ă-mē'nō-ter'min-ăl),
The α-NH2 group or the aminoacyl residue containing it at one end of a peptide or protein (usually on the left as written).
Synonym(s): NH2-terminal
Farlex Partner Medical Dictionary © Farlex 2012

a·mi·no-ter·mi·nal

(ă-mē'nō-tĕr'mi-năl)
The α-NH2 group or the aminoacyl residue containing it at one end of a peptide or protein (usually at left as written).
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Clearance of NH2-terminal propeptides of types I and III procollagen is a physiological function of the scavenger receptor in liver endothelial cells.
It has the capacity of activation both in the absence and presence of fibrin by "catalytic switch" that contains NH2-terminal. Mutant SK lacking NH2-terminal is unable to activate plasminogen by fibrin independent mechanism (Loy et al., 2001).
Fenofibrate attenuates pressure overload-induced cardiac hypertrophy partly by inhibiting the binding of p65-NF[kappa]B to NFATc4, the c-Jun NH2-terminal kinase pathway, ERK activation, and MMP2 activity, as well as increasing high mobility group box 1 (HMGB1) levels in nuclei [12, 15, 33, 34].
The c-Jun NH2-terminal kinase is activated by multiple forms of stress and has been proven to be a mediator of stress-induced apoptosis.[sup][21] Manipulation of JNK/MAPK pathway could be a potential therapeutic target for acute respiratory distress syndrome (ARDS) in the context of suppressing inflammation.[sup][22] Western blotting results showed that, like GSH, BV treatment decreased the phosphorylation of JNK which was greatly induced in the I/R group ( P < 0.01) [Figure 3].{Figure 3}
5-Fluorouracil blocks transforming growth factor-beta-induced alpha 2 type I collagen gene (COLIA2) expression in human fibroblasts via c-Jun NH2-terminal kinase / activator protein-1 activation.
Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mucalpain cleavage.
Midazolam decreases the expression of pAkt and Akt and upregulates the phosphorylation of p38 and c-Jun NH2-terminal kinase, rather than extracellular signal-regulated kinases [29].
MAPK (mitogen-activated protein kinase); ERK (extracellular signal-regulated kinase); JNK (c-Jun NH2-terminal kinase) with the degradation of the inhibitor IkappaB kinase, cause the translocation of NFkB from the cytoplasm to the nucleus, resulting in the activation of AP-1 (activator protein 1), NFkB and CREB (cAMP-responsive-binding protein) transcription factors.
Stark, On the reversible reaction of cyanate with sulfhydryl groups and the determination of NH2-terminal cysteine and cystine in proteins, J.
B cell activating factor (BAFF) belongs to the tumor necrosis factor (TNF) family and is also known as B-lymphocyte stimulator (BLyS), TNF and ApoL-related leukocyte-expressed ligand-1 (TALL-1), TNF homologue that activates apoptosis, nuclear factor-[kappa]B, and c-Jun NH2-terminal kinase (THANK), and TNF superfamily member 13B (TNFSF 13B).
Donget al., "Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of c-Jun NH2-terminal kinase signaling," Diabetes, vol.
Stabilizing the long NH2-terminal helix pair of GrpE by an engineered disulfide bond abolishes the thermal transition in GrpE and reduces the deviation of the ADP/ATP exchange activity of GrpE from an Arrhenius temperature dependence, indicating that the long helix pair acts as the primary thermosensor of the chaperone system.