NFKB1

(redirected from NFkappaB)

NFKB1

A gene on chromosome 4q24 that encodes a kappa light polypeptide of NF-kappaB (nuclear factor-kappaB), a rapidly acting primary transcription factor which is found in all cell types and involved in cellular responses to stimuli, including cytokines and stress. NF-kappaB plays a key role in regulating the immune response to infection; it is involved in various biological processes including inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis.
References in periodicals archive ?
NFkappaB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts.
Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.
In addition, TNFa also triggers NFkappaB activation, which induces stellate cell activation and conversion into collagen secreting myofibroblasts.
ENMD-1198 Antitumor Activity and Inhibition of HIF-1alpha, STAT3 and NFkappaB Signaling Pathways are Dependent on Microtubule Isotype Expression and Targeting," Monday, April 14, 2008 from 1:00 PM - 5:00 PM -- "Combination Therapy of MKC-1 and Paclitaxel Synergistically Inhibits Tumor Growth in the MDA-MB-231 Orthotopic Breast Cancer Tumor Model," Tuesday, April 15, 2008, 8:00 AM - 12:00 PM.
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases.
A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species.
AGEs accumulate in the heart and large blood vessels in diabetics, interacting with receptors such as RAGE to induce oxidative stress, increasing inflammation by promoting NFkappaB activation, and enhancing extracellular matrix accumulation.
The oestrogen receptor regulates NFkappaB and AP-1 activity in a cell-specific manner.
Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels.
Part of the rationale for this combination stems from the inhibition of the nuclear transcription factors, NFkappaB and HIF-1alpha, by Velcade(R) and Panzem(R), respectively.