NFKB1

(redirected from NFkappaB)

NFKB1

A gene on chromosome 4q24 that encodes a kappa light polypeptide of NF-kappaB (nuclear factor-kappaB), a rapidly acting primary transcription factor which is found in all cell types and involved in cellular responses to stimuli, including cytokines and stress. NF-kappaB plays a key role in regulating the immune response to infection; it is involved in various biological processes including inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis.
References in periodicals archive ?
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.
Curcumin inhibits mitogen stimulated lymphocyte proliferation, NFkappaB activation, and IL-2 signaling.
Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidation-driven activation of the PKC-PI3K-Akt pathway.
2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NFkappaB signalling.
Expression in glomerular cells in vitro and in vivo by transcription factor decoy for NFkappaB.
Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3.
Alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrialrelated pathway, involves p53 and NFkappaB.
Ghosh-Choudhury T, Mandal CC, Woodruff K, St Clair P, Fernandes G (2009) Fish oil targets PTEN to regulate NFkappaB for down regulation of antiapoptotic genes in breast tumor growth.
Anti-inflammatory effect of Ishige okamurae ethanolic extract via inhibition of NFkappaB transcription factor in RAW 264.
Vitamin D decreases NFkappaB activity by increasing kappaBalpha levels.