NFKB1

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NFKB1

A gene on chromosome 4q24 that encodes a kappa light polypeptide of NF-kappaB (nuclear factor-kappaB), a rapidly acting primary transcription factor which is found in all cell types and involved in cellular responses to stimuli, including cytokines and stress. NF-kappaB plays a key role in regulating the immune response to infection; it is involved in various biological processes including inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis.
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Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity.
Detrimental effects of lipopolysaccharides on maturation of bovine oocytes
The role of nitric oxide in the particulate matter (PM2.5)-induced NFkappaB activation in lung epithelial cells.
Glucose Homeostasis following Diesel Exhaust Particulate Matter Exposure in a Lung Epithelial Cell-Specific IKK2-Deficient Mouse Model
Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NFkappaB signaling pathway.
Effect of Pomegranate on Cancer Formation and Growth
In the study of ovarian cancer, the functional activity for TLRs was demonstrated by the stimulation of cell lines with specific ligands and subsequent activation and translocation of NFkappaB and release of the proinflammatory cytokines interleukin-6 and CCL-2 (27).
Association between small intestinal bacterial overgrowth and toll-like receptor 4 in patients with pancreatic carcinoma and cholangiocarcinoma
Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels.
Vitamin D Deficiency in Premature Infants and Its Effects on Neonatal Prognosis
Stimulation of macrophage migration inhibitory factor expression in endometrial stromal cells by interleukin 1, beta involving the nuclear transcription factor NFkappaB. Biol Reprod 2005;73:565-70.
Tumor necrosis factor alfa and interleukin 1 alfa induced phosphorylation and degradation of inhibitory kappa B alpha are regulated by estradiol in endometrial cells/Endometriyal hucrelerdeki inhibitor kappa B alfa'nin tumor nekroz faktoru ve interlokin 1 induklenmis fosforilasyonunu estradiol ile ayarlanir
Carrageenan-induced NFkappaB activation depends on distinct pathways mediated by reactive oxygen species and hsp27 or by bcl10.
The influence of carrageenan on markers of endogenous intoxication in rats
Busse, "Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NFkappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells," Circulation, vol.
Dilating Vascular Diseases: Pathophysiology and Clinical Aspects
Jimenez, "NFkappaB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis," Annals of the Rheumatic Diseases, vol.
Exposure of Macrophages to Low-Dose Gadolinium-Based Contrast Medium: Impact on Oxidative Stress and Cytokines Production
Gatti et al., "Atorvastatin downregulates monocyte CD36 expression, nuclear NFkappaB and TNFalpha levels in type 2 diabetes," Journal of Atherosclerosis and Thrombosis, vol.
Is Atorvastatin Associated with New Onset Diabetes or Deterioration of Glycemic Control? Systematic Review Using Data from 1.9 Million Patients
LPS-activated TRL4 activates the NFkappaB pathway and all three MAPK pathways (ERK, JNK/SAPK, and p38).
Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats

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