Toll-like receptors: from the discovery of NFkappaB
to new insights into transcriptional regulations in innate immunity.
The role of nitric oxide in the particulate matter (PM2.5)-induced NFkappaB
activation in lung epithelial cells.
Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NFkappaB
In the study of ovarian cancer, the functional activity for TLRs was demonstrated by the stimulation of cell lines with specific ligands and subsequent activation and translocation of NFkappaB
and release of the proinflammatory cytokines interleukin-6 and CCL-2 (27).
Vitamin D decreases NFkappaB
activity by increasing IkappaBalpha levels.
Stimulation of macrophage migration inhibitory factor expression in endometrial stromal cells by interleukin 1, beta involving the nuclear transcription factor NFkappaB
. Biol Reprod 2005;73:565-70.
activation depends on distinct pathways mediated by reactive oxygen species and hsp27 or by bcl10.
Busse, "Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NFkappaB
and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells," Circulation, vol.
activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis," Annals of the Rheumatic Diseases, vol.
Gatti et al., "Atorvastatin downregulates monocyte CD36 expression, nuclear NFkappaB
and TNFalpha levels in type 2 diabetes," Journal of Atherosclerosis and Thrombosis, vol.
LPS-activated TRL4 activates the NFkappaB
pathway and all three MAPK pathways (ERK, JNK/SAPK, and p38).