NFKB1

(redirected from NFkappaB)

NFKB1

A gene on chromosome 4q24 that encodes a kappa light polypeptide of NF-kappaB (nuclear factor-kappaB), a rapidly acting primary transcription factor which is found in all cell types and involved in cellular responses to stimuli, including cytokines and stress. NF-kappaB plays a key role in regulating the immune response to infection; it is involved in various biological processes including inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis.
References in periodicals archive ?
Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity.
The role of nitric oxide in the particulate matter (PM2.5)-induced NFkappaB activation in lung epithelial cells.
Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NFkappaB signaling pathway.
In the study of ovarian cancer, the functional activity for TLRs was demonstrated by the stimulation of cell lines with specific ligands and subsequent activation and translocation of NFkappaB and release of the proinflammatory cytokines interleukin-6 and CCL-2 (27).
Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels.
Carrageenan-induced NFkappaB activation depends on distinct pathways mediated by reactive oxygen species and hsp27 or by bcl10.
Busse, "Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NFkappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells," Circulation, vol.
Jimenez, "NFkappaB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis," Annals of the Rheumatic Diseases, vol.
Gatti et al., "Atorvastatin downregulates monocyte CD36 expression, nuclear NFkappaB and TNFalpha levels in type 2 diabetes," Journal of Atherosclerosis and Thrombosis, vol.
LPS-activated TRL4 activates the NFkappaB pathway and all three MAPK pathways (ERK, JNK/SAPK, and p38).