NFKBIA


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NFKBIA

A gene on chromosome 14q132 that encodes an I-kappa-B protein that inhibits the multimeric NFKB complex by trapping it in the cytoplasm. Kinases IKBKA or IKBKB phosphorylate NFKBIA’s serine residues, marking them for destruction via the ubiquination pathway, allowing activation of the NFKB complex which, once activated, translocates to the nucleus, binds DNA and activates transcription.
References in periodicals archive ?
The investigators analyzed several hundred tumor samples collected from glioblastoma patients treated at several institutions between 1989 and 2009, and found NFKBIA deletions in a surprisingly high proportion, 25 percent, of the samples.
Moreover, the authors learned, patients with either the NFKBIA or EGFR abnormality had a significantly shorter survival, despite maximal therapy, than the remaining patients whose tumors bore neither genetic defect.
The defects on NFKBIA and EGFR have a similar effect on an important molecule called NF-kappa-B, a "transcription factor" found in all cells, but they do this by different mechanisms.