To test our hypothesis, we conducted a case-control study to investigate the association of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -826C>T and -881A>G polymorphisms with the risk of lung cancer in a Chinese population.
Association of NFKB1 and NFKBIA polymorphisms with lung cancer risk: The association between NFKB1 and NFKBIA polymorphisms and lung cancer risk is shown in Table-I.
Table-I: Association between NFKB1 -94 ins/del ATTG polymorphism, NFKBIA -826C>Tpolymorphism and NFKBIA -881A>G polymorphism and lung cancer risk.
Table-II: Association between combinations of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -826C>T polymorphism and lung cancer risk.
Table-III: Association between combinations of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -881A>G polymorphism and lung cancer risk.
Combinations of polymorphisms and lung cancer risk: The association of combinations of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -826C>T polymorphism with lung cancer risk is shown in Table-II.
Table-IV: Association between combinations of NFKBIA -826C>T polymorphism and NFKBIA -881A>G polymorphism and lung cancer risk.
The combinations of NFKBIA -826C>T polymorphism and NFKBIA -881A>G polymorphism and their association with lung cancer risk is shown in Table-IV.
Analysis of NFKBIA -826C>T risk association by gender and smoking status: The association between NFKBIA -826C>T polymorphism and lung cancer risk according to sex and smoking status is shown in Table-VI..
In our study, UFPs altered the expression of many of the genes in these processes, including FOS (1.6-fold), JUN (1.3-fold), NFKBIA (1.3-fold), and early growth response-1 (EGR-1, Unigene accession no.
Gene symbol Gene name change 517617 MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F 1.7 25292 JUNB jun B proto-oncogene 1.7 590958 FOSB FBJ murine osteosarcoma viral 1.5 oncogene homolog B 132225 PIK3R1 phosphoinositide-3-kinase, 1.5 regulatory subunit 1 155396 NRF2 nuclear factor (erythroid-derived 1.3 2)-like 2 534313 EGR3 early growth response 3 1.3 81328 NFKBIA nuclear factor of kappa light 1.3 polypeptide gene enhancer in B-cells inhibitor, alpha 252229 MAFG v-maf musculoaponeurotic 1.2 fibrosarcoma oncogene homolog G (avian) 326035 EGR1 early growth response 1 1.2 Gene annotations are from Unigene (http://www.ncbi.nlm.nih.gov/entrez/ query.fcgi?db=unigene).