NFKBIA


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NFKBIA

A gene on chromosome 14q132 that encodes an I-kappa-B protein that inhibits the multimeric NFKB complex by trapping it in the cytoplasm. Kinases IKBKA or IKBKB phosphorylate NFKBIA’s serine residues, marking them for destruction via the ubiquination pathway, allowing activation of the NFKB complex which, once activated, translocates to the nucleus, binds DNA and activates transcription.
References in periodicals archive ?
Combinations of polymorphisms and lung cancer risk: The association of combinations of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -826C>T polymorphism with lung cancer risk is shown in Table-II.
Table-IV: Association between combinations of NFKBIA -826C>T polymorphism and NFKBIA -881A>G polymorphism and lung cancer risk.
Analysis of NFKBIA -826C>T risk association by gender and smoking status: The association between NFKBIA -826C>T polymorphism and lung cancer risk according to sex and smoking status is shown in Table-VI.
Analysis of NFKBIA -881A>G risk association by gender and smoking status: The association between NFKBIA -881A>G polymorphism and the risk of lung cancer according to sex and smoking status is shown in Table-VII.
Table-VI: Association between NFKBIA -826C>T polymorphism and lung cancer risk according to sex and smoking status.
Table-VII: Association between NFKBIA -881A>G polymorphism and lung cancer risk according to sex and smoking status.
We have also showed in the current study that the variant genotypes of NFKBIA -826C>T and -881A>G polymorphisms could increase lung cancerrisk.
21 showed that the heterozygous genotype of both the NFKBIA -826C>T and -881A>G polymorphisms increased the risk of oral cancer among Chinese.