NFKB1


Also found in: Acronyms, Wikipedia.

NFKB1

A gene on chromosome 4q24 that encodes a kappa light polypeptide of NF-kappaB (nuclear factor-kappaB), a rapidly acting primary transcription factor which is found in all cell types and involved in cellular responses to stimuli, including cytokines and stress. NF-kappaB plays a key role in regulating the immune response to infection; it is involved in various biological processes including inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis.
References in periodicals archive ?
The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-[kappa]B1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis.
In the PPI network constructed on the basis of these genes and their interactions, JUN, TNF, NFKB1, and FOS were established as hub nodes according to their BC, closeness centrality, and DC scores.
Results: We found a significant risk reduction associated with heterozygous ins/del (OR=0.705, 95% CI=0.566-0.878, P=0.002) and variant del/del (OR=0.342, 95% CI=0.221-0.528, Pless than 0.001) genotypes of the NFKB1 polymorphism.
Immune response genes selected for the study (TLR2, NFKB1, IL2, IL16, TNF, IFNG, CXCR3, CCL1, CD81, CD84, RPS6KB2, STK17B, PRKCB1, MCL1, EEF1G, NFATC4, EEF1 and IER5) were amplified from cDNA of PBMCs (Fig.
The proteins were resolved by SDS-PAGE, transferred to a polyvinylidene fluoride membrane and incubated overnight at 4[degrees]C with primary antibodies against phospho (P)-SMAD 1/5/8 (Cell Signaling, USA), SMAD 1/5/8 (Abcam, USA), NFKB1 (Cell Signaling), c-Fos (Cell Signaling), p-P38 (Cell Signaling), p-JNK and p-I[kappa]B (Anbobio, China).
In particular, NFKB1 and DLX1 increased their expression (50% and 30% increased expression, resp.; P = 0.04 and 0.03, resp.).
* Gene variant linked to lung cancer risk a variation of the gene NFKB1, called rs4648127, is associated with an estimated 44% reduction in lung cancer risk.
A variation of the gene NFKB1, called rs4648127, is associated with an estimated 44 percent reduction in lung cancer risk.
Association of NFKB1, which encodes a sub-unit of the transcription factor NF-kappaB, with alcohol dependence.
In fibroblasts, wild-type v-Rel induced expression of mip1beta and nfkb1, while non transforming mutants of v-Rel failed to do so, suggesting a role for these two genes in v-Rel mediated transformation.
Insertion/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome.
Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence.