NFKB1


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NFKB1

A gene on chromosome 4q24 that encodes a kappa light polypeptide of NF-kappaB (nuclear factor-kappaB), a rapidly acting primary transcription factor which is found in all cell types and involved in cellular responses to stimuli, including cytokines and stress. NF-kappaB plays a key role in regulating the immune response to infection; it is involved in various biological processes including inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis.
References in periodicals archive ?
Association of NFKB1 and NFKBIA polymorphisms with lung cancer risk: The association between NFKB1 and NFKBIA polymorphisms and lung cancer risk is shown in Table-I.
Table-I: Association between NFKB1 -94 ins/del ATTG polymorphism, NFKBIA -826C>Tpolymorphism and NFKBIA -881A>G polymorphism and lung cancer risk.
Table-II: Association between combinations of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -826C>T polymorphism and lung cancer risk.
Table-III: Association between combinations of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -881A>G polymorphism and lung cancer risk.
Combinations of polymorphisms and lung cancer risk: The association of combinations of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -826C>T polymorphism with lung cancer risk is shown in Table-II.
Table-V: Association between NFKB1 -94 ins/del ATTG polymorphism and lung cancer risk according to sex and smoking status.
Analysis of NFKB1 risk association by gender and smoking status: The stratified association between the NFKB1 polymorphism and lung cancer risk according to gender and smoking status is shown in Table-V.
We haveshowed that the variant del genotype of the NFKB1 -94 ins/del ATTG polymorphism could significantly reduce lung cancerrisk.
Similar to the NFKB1 -94 ins/del ATTG polymorphism, our results are contrary to the results of Huang et al.
We have showed that the variant alleles of NFKB1 -94 ins/del ATTG polymorphism, NFKBIA -826C>T polymorphism and NFKBIA -881A>G polymorphism could influence the risk of lung cancer in China.