NFATC2

NFATC2

A gene on 20q13.2 that encodes a member of the nuclear factor of activated T cells (NFAT) family, which is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). NFATC2 is present in the cytosol and translocates to the nucleus after T-cell receptor (TCR) stimulation where it becomes a member of the NFAT transcription complex, which plays a central role in inducing gene transcription during the immune response.
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In a recent study, the expression of neurotrophins derived from the brain was compared with neuropeptides in HNSCC, indicating that activated GALR2 induces the activated cytoplasmic T cell nuclear factor, calcineurin-2-mediated transcription (NFATC2) of cyclooxygenase-2 (COX2), which stimulates the production of prostaglandin E2 (PGE2), promoting tumor progression [129].
Several partners of EWSR1 are described: POU5F1 (6p21.33) (16%), PBX1 (16%), PBX3, ZNF444, ATF1, KLF17, and NFATC2 [10-16].
In a recent study, decreased SIRT3 in human pulmonary artery smooth cell was associated with an induction of transcription factors HIF-1alpha, signal transducer and activator of transcription3 (STAT3), and nuclear factor of activated T-cells cytoplasmic 2 (NFATc2) and was associated with pulmonary arterial hypertension [119].
NFATc3 or NFATc2 and nuclear regions were detected by monitoring Cy5 and green fluorescence, respectively, on a Zeiss LSM 5 laser scanning confocal microscope.
NFATc2 and NFATc3 were readily detected in whole retina from mouse, whereas expression of NFATc1 was very low and of NFATc4 very low to undetectable (Figure 1(a)).
It has been shown that adult NFATc2 knockout mice exhibit extramedullary hematopoiesis and suffer from osteomyelosclerosis and hypoplasia in the bone marrow (with significant losses of erythrocytes, lymphocytes, and megakaryocytes) [30].
The NFAT (formally NFATc) family consists of several members: NFAT1 (NFATp, NFATc2), NFAT2 (NFATc, NFATc1), NFAT3 (NFATc4), NFAT4 (NFATx, NFATc3), and NFAT5.
(24-27) In addition, a fusion between EWSR1 and a gene from a transcription factor family other than ETS, the NFATC2 gene (encodes for a member of the NFAT transcription factor family), has been described.
Gene symbol Gene name change 211869 DKK2 dickkopf homolog 2 1.9 592141 NFATC2 nuclear factor of activated T-cells, 1.8 cytoplasmic, calcineurin-dependent 2 599590 SOX17 SRY (sex determining region Y)-box 1.4 17 6347 LRP5 low density lipoprotein receptor- 1.3 related protein 5 525704 JUN v-jun sarcoma virus 17 oncogene 1.3 homolog 283565 FOSL1 fos-like antigen 1 1.2 351887 CAMK2B calcium/calmodulin-dependent protein 1.2 kinase II beta 149413 PPP3CC protein phosphatase 3, catalytic 1.2 subunit, gamma isoforms (calcineurin A gamma) 94234 FZD1 frizzled homolog 1 0.8 591968 FZD4 frizzled homolog 4 0.8 524348 PRICKLE1 prickle-like 1 0.8 Gene annotations are from Unigene (http://www.ncbi.nlm.nih.gov/entrez/ query.fcgi?db=unigene).
Serfling et al., "NFATc2 and NFATc3 transcription factors play a crucial role in suppression of [CD4.sup.+] T lymphocytes by [CD4.sup.+] CD25+ regulatory T cells," Journal of Experimental Medicine, vol.