NFATC1

NFATC1

A gene on chromosome 18q23 that encodes a DNA-binding member of the nuclear factor of activated T cells (NFAT) family, which play a central role in inducible gene transcription during the immune response. NFATC1 is an inducible nuclear component and a major molecular target for immunosuppressive drugs, such as cyclosporin A.
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After being blocked for 1 h at room temperature, the membrane was incubated with a 1:1000 dilution of rabbit polyclonal anti-mouse TRAF6, NFATc1, and [beta]-actin antibody (ABGENT, USA) overnight.
MAPK10 activity is inhibited by MDS1 and EVI1 complex locus (MECOM) and nuclear factor of activated T-cells 1 (NFATC1), which were also overexpressed in the 45-day-old chickens (see Figure S1).
Studies on murine hair follicles have also revealed expression of, inter alia, CK19 [8, 22] and numerous transcription factors, that is, Sox9, Lgr5, Gli1, Hopx, LHX2, Nfatc1, and Tcf3 [8, 25].
Several proteins are involved in osteoclastogenesis such as RANKL, NK-[kappa]B, TNF, macrophage colony stimulating factor (M-CSF), and nuclear factor of activated T cells (NFATC1) [36].
It reduces the expression of NFATc1 protein induced by RANKL stimulation and inhibits the OC precursors by targeting expression of RhoA and Rac1, GTPases involved in cellular motility [74].
RANKL-RANK interaction activates the master transcription factor for osteoclastogenesis; nuclear factor of activated T cells, cytoplasmic 1 (NFATc1); tartrate-resistant acid phosphatase; calcitonin receptor; and cathepsin K [27].
Myricetin suppresses LPS-induced MMP expression in human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL-induced RAW 264.7 cells.
Antibodies such as SM-MHC (Abcam, USA), NFATc1 (CST, USA), vimentin (Immunoway, USA), calponin (Abcam, USA), and [alpha]-SMA (Sigma, USA) were used to observe the phenotype transformation of CD137 axis.
demonstrated that barley seedling extracts (BSE) dose-dependently inhibited RANKL-induced osteoclast differentiation with alteration of I[kappa]B degradation, c-Fos, and NFATc1 molecules in the early-to-middle stages of osteoclastogenesis.
Another study recruited 27 patients and revealed the significant level of DNA methylation of NFATC1, GSTP1, CDKN2A, and BMP4 genes in HCC tissues [12].
Cur was capable of blocking [Ca.sup.2+]-dependent NFATc1 transcriptional activity, COX-2 and mPGES-1 induction, and subsequent [PGE.sub.2] production in ET-1-stimulated and parasite-infected cardiomyocytes.
By manipulating expression of Foxc1 at different stages of the hair growth cycle, researchers determined that this transcription factor promotes signaling between two key mechanisms that control quiescence, Nfatc1 and BMP.