NFATC1

NFATC1

A gene on chromosome 18q23 that encodes a DNA-binding member of the nuclear factor of activated T cells (NFAT) family, which play a central role in inducible gene transcription during the immune response. NFATC1 is an inducible nuclear component and a major molecular target for immunosuppressive drugs, such as cyclosporin A.
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Accordingly, CALM1 [calmodulin 1 (phosphorylase kinase, [delta])] rs12885713; IL2 (interleukin-2) rs2069762; IL2RA (interleukin 2 receptor, [alpha]) rs7090530, rs10795791, rs11594656, rs35285258; JUN (jun proto-oncogene) rs2760501, rs4646999; and NFATC1 (nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1) rs754093 were genotyped by means of Taqman[R] allelic discrimination assays with a Rotor-Gene Q 2plex HRM (Qiagen), according to the manufacturer's protocol.
8] Human genes: PPIA, peptidylprolyl isomerase A (cyclophilin A); PPP3R1, protein phosphatase 3, regulatory subunit B, a; PPP3CA, protein phosphatase 3, catalytic subunit, a isozyme; PPP3CB, protein phosphatase 3, catalytic subunit, isozyme; FKBP1A, FK506 binding protein 1A, 12 kDa; CALM1, calmodulin 1 (phosphorylase kinase, 8); IL2, interleukin-2; IL2RA, interleukin 2 receptor, a; JUN, jun proto-oncogene; NFATC1, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1.
NFATC1, which normally exerts a proapoptotic effect (but in the NFATC1/aA1 form is an oncogene), is silenced by promoter hypermethylation in ALCL.