NFATC1

(redirected from NFAT2)

NFATC1

A gene on chromosome 18q23 that encodes a DNA-binding member of the nuclear factor of activated T cells (NFAT) family, which play a central role in inducible gene transcription during the immune response. NFATC1 is an inducible nuclear component and a major molecular target for immunosuppressive drugs, such as cyclosporin A.
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NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased bax expression.
Koga et al., "Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts," Developmental Cell, vol.
Osterix (Osx) is a downstream factor of Runx2 that binds to activated NFAT2 in bone development [47].
The losses of NFAT1 and NFAT2 in [CD4.sup.+] T cells impair the expression of [T.sub.FH] differentiation-associated molecules such as ICOS and PD-1 [12].
The differences of gene expressions of NFAT4, NFAT2, and IL-1[beta] were not obvious after initiation of HAART (fold difference: 0.969, 0.981, and 1.03, resp.).
The IRIS group showed lower IL-6 and IL-8 expression levels than the non-IRIS group, whereas other genes including NFAT4, NFAT3, NFAT2, IL-1[beta], IL-10, IL-2, IL-18, and TNF-[alpha] were expressed at higher levels in the IRIS group than in the non-IRIS group.
The NFAT (formally NFATc) family consists of several members: NFAT1 (NFATp, NFATc2), NFAT2 (NFATc, NFATc1), NFAT3 (NFATc4), NFAT4 (NFATx, NFATc3), and NFAT5.
Shi et al., "NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice," British Journal of Pharmacology, vol.
Kim, T Koga et al., "Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts," Developmental Cell, vol.
Hoshijima et al., "Large scale gene exp ression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator," Journal of Biological Chemistry, vol.