NFATC2

(redirected from NFAT1)

NFATC2

A gene on 20q13.2 that encodes a member of the nuclear factor of activated T cells (NFAT) family, which is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). NFATC2 is present in the cytosol and translocates to the nucleus after T-cell receptor (TCR) stimulation where it becomes a member of the NFAT transcription complex, which plays a central role in inducing gene transcription during the immune response.
References in periodicals archive ?
The NFAT family includes five members, NFAT1 to NFAT5, which are all regulated by Ca[sup]2+/Cn signal except NFAT5.
Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation.
With respect to multisite phosphorylation or dephosphorylation, pathway simulation predicted that activation of transcription factor NFAT1 (nuclear factor of activated T cells) is ultrasensitive with a threshold (Salazar and Hofer 2003).
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.
We measured the inhibition of NFAT1 nuclear translocation, the intracellular expression of IL-2 in [CD4.
cells were studied as a function of NFAT1 expression by use of a large variety of models classically used for enzyme inhibition or receptor response, as well as simpler linear and nonlinear regression models.
ALTERACOES MORFOLOGICAS NOS TESTICULOS DE CAMUNDONGOS KNOCKOUT PARA NFAT1.
A deficiencia de NFAT1 tem sido relacionada ao crescimento celular descontrolado e diferenciacao de celulas do tecido conjuntivo e muscular esqueletica, sugerindo seu papel no controle negativo de genes relacionados com o ciclo e diferenciacao celular (Viola et al, 2005).
The NFAT (formally NFATc) family consists of several members: NFAT1 (NFATp, NFATc2), NFAT2 (NFATc, NFATc1), NFAT3 (NFATc4), NFAT4 (NFATx, NFATc3), and NFAT5.
Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.
ESTUDO ESTRUTURAL E MORFOMETRICO DE PROSTATAS DE CAMUNDONGOS NORMAIS E KNOCKOUT PARA NFAT1.