NFAM1

NFAM1

A gene on 22q13.2 that encodes a type-I membrane receptor that activates cytokine gene promoters (e.g., IL-13) and TNF-alpha promoters. NFAM1 contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate B-cell signalling and development.
References in periodicals archive ?
Nuclear factor of activated T cells-(NFAT-) activating molecule 1 (NFAM1), which is an ITAM-containing cell surface molecule, also binds with Syk through its phosphorylated ITAM motif [39].
Takeuchi et al., "NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling," Proceedings of the National Academy of Sciences of the United States of America, vol.