NF-kappaB


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NF-κB

a transcription factor that regulates cytokine gene transcription. NF-κB is a target of glucocorticoid action.

NF-kappaB

A pleiotropic transcription factor present in most cell types, which is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis. It forms a homo- or heterodimeric complex with Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52, binding the kappa-B sites in the DNA of their target genes. Individual dimers have distinct preferences for different kappa-B sites, binding with distinct affinity and specificity; different dimer combinations act as transcriptional activators or repressors.

NF-kappaB is controlled by various mechanisms of post-translational modification and subcellular compartmentalisation, as well as by interactions with other cofactors or co-repressors. NF-kappaB complexes are held in the cytoplasm in an inactive state, complexed with members of the NF-kappaB inhibitor (I-kappa-B) family. In conventional activation, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators and subsequently degraded, liberating the active NF-kappaB complex, which translocates to the nucleus.
References in periodicals archive ?
The role of NF-kappaB factor REL2 in the Aedes aegypti immune response.
(17) Another study reported that vanillin enhanced TRAIL-induced apoptosis in cancer cells by inhibiting NF-KappaB activation, an action that is often reported to be how curcumin triggers cancer cell death.
Pomegranate accomplishes this by turning off genes related to inflammation, such as reducing activity of proinflammatory NF-kappaB. (9,10)
Effects of benzo[a]pyrene exposure on human hepatocellular carcinoma cell angiogenesis, metastasis, and NF-kappaB signaling.
(2.) Kaponis A, Iwabe T, Taniguchi F, Ito M, Deura I, Decavalas G, Terakawa N, Harada T: The role of NF-kappaB in endometriosis.
NF-kappaB transcription factor p50 critically regulates tissue factor in deep vein thrombosis.
Er-Miao-San, a traditional herbal formula containing Rhizoma atractylodis and Cortex phellodendri, inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-kappaB pathway and MAPKs activation.
Baltimore, "MicroRNAs, new effectors and regulators of NF-kappaB," Immunological Reviews, 2012; 246(1): pp.
TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells.