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a transcription factor that regulates cytokine gene transcription. NF-κB is a target of glucocorticoid action.


A pleiotropic transcription factor present in most cell types, which is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis. It forms a homo- or heterodimeric complex with Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52, binding the kappa-B sites in the DNA of their target genes. Individual dimers have distinct preferences for different kappa-B sites, binding with distinct affinity and specificity; different dimer combinations act as transcriptional activators or repressors.

NF-kappaB is controlled by various mechanisms of post-translational modification and subcellular compartmentalisation, as well as by interactions with other cofactors or co-repressors. NF-kappaB complexes are held in the cytoplasm in an inactive state, complexed with members of the NF-kappaB inhibitor (I-kappa-B) family. In conventional activation, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators and subsequently degraded, liberating the active NF-kappaB complex, which translocates to the nucleus.
References in periodicals archive ?
The rejuvenated skin returned to its elderly look after about two weeks because the action of bleach on NF-kB is mild, and diminishes with time.
Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression Cancer Letters.
He found that exposure to the solution blocked the expression of two genes known to be regulated by NF-kB.
When TRAF3 evades attack, it turns that same destructive mechanism against NIK, a protein that is central to NF-kB activity, by tagging it with ubiquitins.
It was concluded that phytochemicals such as eugenol that are capable of targeting NF-kB signaling pathway, by manipulating the equilibrium between pro- and anti-apoptotic proteins as well as the delicate balance between stimulators and inhibitors of invasion and angiogenesis are attractive candidate for preventing tumour progression.
The claims at issue in Ariad's '516 patent were to nonspecific methods for reducing external effects on cells that induce NF-KB signaling in cells, methods for reducing expression of cytokines by reducing binding to the NF-KB activation sites on genes, and methods for reducing NF-KB expression in eukaryotic cells.
3]-induced pulmonary inflammation via modulation of expression of inflammatory mediators CD86 and MIP-2 and nuclear transcription factors NF-kB and STAT3.
The studies cover folate biosynthesis and new antimicrobials; anti-cancer agents, including cytotoxic drugs from medicinal plants; applications of quantum dots in medicinal chemistry and drug development; copper and vanadium bioactive compounds and their effects on bone-related cells; antimalarial peroxides; marine NF-kB inhibitors; and layered double hydroxides and their intercalation compounds.
In this research, funded by the Medical Research Council and the British Liver Trust, the Newcastle University researchers discovered a biological marker, NF-kB, was crucial for the activities of scar-forming cells.
The Cardiff University team have discovered that large amounts of a protein called NF-kB are linked to the growth of chronic lymphocytic leukaemia-the most common form of the disease in adults in the UK.
Dong Ju Son of National University, Chungbuk, Korea, and colleagues targeted the antiapoptotic transcriptional factor called NF-KB, which is activated in prostate cancer cell lines, by culturing prostate cancer cells with a toxin called Vipera lebetina turanica.