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Ozone enhances diesel exhaust particles (DEP)-induced interleukin-8 (IL-8) gene expression in human airway epithelial cells through activation of nuclear factors-kappaB (NF-kappaB) and IL-6 (NF-IL6
Although NF-[kappa]B is thought of as a genetic switch that can control early-response gene expression, the synergistic interaction of NF-[kappa]B with other transcription factors such as Stat (14, 15), Ap-1 (16), cAMP-response element binding protein (17), nuclear factor AT (18, 19), and NF-IL6 (20) is required to achieve a purposeful induction of a particular gene.
There is also some evidence to show that occupied estrogen receptors inhibit IL-6 gene expression by preventing the binding of NF-[kappa]B and NF-IL6 transcription factors to their respective binding sites in the IL-6 gene promoter (69).
Regulation of expression of the interleukin 6 gene: structure and function of the transcription factor NF-IL6
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