KIRREL

(redirected from NEPH1)

KIRREL

A gene on chromosome 1q21-q25 that encodes a protein which plays a key role in the development and function of glomerular permeability. KIRREL trans-activates the transcription factor AP-1 in the presence of TEC kinases. It is primarily located at the podocyte slit diaphragm.
References in periodicals archive ?
Several proteins such as ZO-1 (zonula occludens-1), nephrin, CD2AP (CD2-associated protein), FAT, P-cadherin, NEPH1 (nephrin-like protein-1), and podocin are expressed within the slit diaphragm.
Some are structural podocyte proteins including those of the slit-diaphragm (nephrin, Neph1), actin associated proteins (alpha-actinin 4) [11], CD2AP [12], and podocin [13].
Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. J Am Soc Nephrol.