NEMO


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NEMO

NF-kB Essential Modulator. A regulatory sub-unit of the inhibitor of NF-kappaB kinase (IKK) complex encoded by IKBKG on chromosome Xq28,  which activates NF-kappaB, triggering activation of genes involved in inflammation, immunity, cell survival, and other pathways. NEMO has an antiapoptotic function independent of its role in the IKK pathway, which prevents receptor-interacting protein-1 (RIP1) from engaging caspase-8 before IKK-mediated induction of antiapoptotic genes. Without NEMO, RIP1 associates with caspase-8, resulting in rapid TNF-induced apoptosis.
 
Abnormal in
IKBKG mutations are linked to incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several immunodeficiencies.
References in periodicals archive ?
Point Nemo was established as a solution to the growing problem of orbiting space junk above Earth.
The NEMO pump with FSIP design is fully compatible with the existing NEMO pump BY and SY series.
The rest of this paper is organized as follows; Section 2 introduces NEMO BSP, while Section 3 represents QoS-aware NEMO protocol.
But for two excellent Murphy saves, Connolly would have augmented the Nemo advantage with a goal.
He was so weak I had to feed him every two hours - I didn't even do that with my own children!" After three weeks of care, Nemo now weighs a healthy 14 ounces, and is looking forward to going to his new home.
Nemo's latest campaign is titled 'Gedari' (My Wall), in Damietta, north of Cairo.
No stranger to technological advancements and industry firsts, NEMO recently introduced its Executive Order (XO), chambered in .308, 6.5 Creedmoor and .260 Remington.
Nemo Xynergy is used as a SaaS (Software as a Service) solution.
''Finding Dory's predecessor, Finding Nemo, received universal acclaim in 2003, and is still regarded as the second highest-grossing film of 2003, only behind 'The Lord of the Rings: Return of the King'.
From next week Nemo, which was established a decade ago, will cease issuing new loans.
Flow bindings is an extension of Multiple Care of Address (MCoA) in Network Mobility (NEMo) that lets a MR to encompass certain flow to a CoA without affecting other flow through a similar home address [2].
Munster Club SFC semi-finals Nemo Rangers (Cork) v Killarney Legion (Kerry) Pairc Ui Rinn, kick-off 2.00pm KILLARNEY outfit Legion find themselves just 60 minutes from a first ever AIB Munster club final place - without being county champions.