NEK9

NEK9

A gene on chromosome 14q24.3 that encodes a NEK serine/threonine protein kinase that acts as a multifaceted regulator of mitotic progression, spindle dynamics and chromosome separation. NEK9 phosphorylates different histones, myelin basic protein, beta-casein, BICD2, histone H3 on serine and threonine residues, and beta-casein on serine residues. It is important for G1/S transition and S-phase progression.
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Recently, it was demonstrated that NC is marked by loss of follicular differentiation markers, and somatic mutations in NEK9 gene may cause the disorder [2].
The functions of Nek6 and Nek7 are concerned with the control of mitotic spindle formation, mutually with the upstream Nek9 in a mitotic kinase cascade [8].
Roig, "Nek9 is a Plkl-activated kinase that controls early centrosome separation through Nek6/7 and Eg5," The EMBO Journal, vol.