NEK3

NEK3

A gene on chromosome 13q14.2-q21.1 that encodes a NEK serine/threonine protein kinase that influences neuronal morphogenesis and polarity by regulating acetylation within the microtubules of neurons. STK1 has prolactin-dependent interaction with PXN, PRLR, VAV1 and VAV2, and has been implicated in prolactin-mediated cytoskeletal reorganisation and motility of breast cancer cells.
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References in periodicals archive ?
By performing meta-analysis combining the five GWAS datasets, we identified 9 CpG-SNPs that were significantly associated with lumbar spine BMD at a genome-wide significance level ([alpha] = 7.86 x [10.sup.-7]), including 5 novel SNPs rs689179 (p value = 2.68 x [10.sup.-7]), rs576118 (p value = 2.70 x [10.sup.-7]), rs471966 (p value = 3.29 x [10.sup.-7]), rs640569 (p value = 4.04 x [10.sup.-7]), and rs667126 (p value=7.80 x [10.sup.-7]) in LRP5 gene and one SNP rs9535889 in novel gene NEK3 (p value =7.55 x [10.sup.-7]).
Notably, the novel SNPs rs9535889, rs9526841, and rs2408611 in NEK3 gene were all located in regions with strong transcription and enhancer activities in PBMs as well as various other tissues and cell types (Table 2), highlighting strong regulatory potential of these CpG-SNPs.
These BMD-associated CpG-SNPs were mapped to six genes; some of which have not been reported for association with BMD in previous GWAS, such as NEK3 and NFATC1 genes.
In summary, we performed a targeted GWAS analysis for potential functional CpG-SNPs and identified 2 novel BMD-associated genes, NEK3 and NFATC1.
Okano, "Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3)," Cytogenetic and Genome Research, vol.
Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.