NEK2

(redirected from NEK2A)

NEK2

A gene on chromosome 1q32.2-q41 that encodes a NEK serine/threonine protein kinase involved controlling centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. It phosphorylates CDC20, CROCC, CEP250, HMGA2, MAD2L1, NDC80, NECAB3, NEK11, NINL, NPM1, PPP1CC and SGOL1; it is essential for localisation of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome.
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References in periodicals archive ?
Zereshki, "NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling," The Journal of Biological Chemistry, vol.
Nek2A kinase regulates the localization of numatrin to centrosome in mitosis.
Purohit, "Insight into Nek2A activity regulation and its pharmacological prospects," Egyptian Journal of Medical Human Genetics, vol.