Furthermore, SCEC tissues were found to possess interactive gene networks with FOXM1, TMPO, KIF11, NEK2
, and CENPF as common skeleton centered on NUF2 (Supplementary information Figure S4).
For instance, the kinases RSK3, MSK1-2, PLK1-3, NEK2
and MEKK1 have larger gatekeepers (e.g.
Detection of IGF2BP3, HOXB7, and NEK2
mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures.
To improve the assay, a numerical score called the molecular grade index (MGI) was created by selecting 5 cell-cycle-related genes (BUB1B, CENPA, NEK2
, RACGAP1, and RRM2) to be used concurrently with the H/I index to improve risk stratification.
In the N-terminal region the amino acidic sequence K-E-N, known as KEN motif, is also present, which serves as targeting signal for Cdh1-APC required also for the degradation of other mitotic proteins such as Nek2
and B99 .
Cell cycle-dependent expression of Nek2
, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.