NEK2

NEK2

A gene on chromosome 1q32.2-q41 that encodes a NEK serine/threonine protein kinase involved controlling centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. It phosphorylates CDC20, CROCC, CEP250, HMGA2, MAD2L1, NDC80, NECAB3, NEK11, NINL, NPM1, PPP1CC and SGOL1; it is essential for localisation of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome.
References in periodicals archive ?
Contracts awarded: Yield-loss-compensation-rights-no: 3quite description: compensation rights for 3~001 - 4~000 m2 nek2
Furthermore, SCEC tissues were found to possess interactive gene networks with FOXM1, TMPO, KIF11, NEK2, and CENPF as common skeleton centered on NUF2 (Supplementary information Figure S4).
Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures.
To improve the assay, a numerical score called the molecular grade index (MGI) was created by selecting 5 cell-cycle-related genes (BUB1B, CENPA, NEK2, RACGAP1, and RRM2) to be used concurrently with the H/I index to improve risk stratification.
In the N-terminal region the amino acidic sequence K-E-N, known as KEN motif, is also present, which serves as targeting signal for Cdh1-APC required also for the degradation of other mitotic proteins such as Nek2 and B99 [22].
Contracts awarded: Afterthought-compensation-rights-no: 1quick description: compensation rights for 500 - 2~000 m2 nek2
Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.