NEK1


Also found in: Acronyms.

NEK1

A gene on chromosome 4q33 that encodes a protein kinase which phosphorylates serines and threonines and has tyrosine kinase activity. NEK1 is thought to have a role in controlling meiosis and in cilia assembly, and it binds to SPERT. It is highly expressed in foetal brain and kidneys.

Molecular pathology
Defects in NEK1 cause short rib-polydactyly syndrome type 2.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The ALS Association is currently funding Landers and Catherine Lutz, Jackson Laboratories, to develop novel mouse models to better understand the consequences of the loss of the NEK1 protein's function for the ALS disease process.
"While further research is needed to understand what part the NEK1 gene plays in the development of MND, it will provide scientists with an important target for developing treatments."
The study, published in (http://www.nature.com/articles/ng.3626.epdf?referrer_access_token=lbprAatGvUK4YWsve9DGCNRgN0jAjWel9jnR3ZoTv0PjhSvNia03_VF3rYLPfJnD6jxt-lWWKtfqBYv-4M0q9EekwROG2VUeDcvQDvsnFxswhCSH_kuNpjM1m31HgsErPt-b1A5gU2oTtC7bH6qvjOTDgyIvtIpc0xUTff5HlXw%3D&tracking_referrer=www.bbc.com) Nature Genetics , says that scientists have identified a new gene contributing to the disease, NEK1. The scientists can now develop a gene therapy to treat it.