NEDD8


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NEDD8

A gene on chromosome 14q12 that encodes a ubiquitin-like protein that plays an important role in cell cycle control and embryogenesis. Covalent attachment of NEDD8 to its substrates (neddylation) requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates E3 ubiquitin ligase activity, promoting polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
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References in periodicals archive ?
Ohh, "pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development," Molecular and Cellular Biology, vol.
Chang et al., "Nedd8 regulates inflammasome-dependent caspase-1 activation," Molecular and Cellular Biology, vol.
NEDD8 was originally identified as a highly expressed molecule in the embryonic brain.
In the present study, we examined the localization of DCUN1D2 and NEDD8 in the sciatic nerves, and found that these neddylation-related molecules were present mainly in the myelin paranodal regions and Schwann cell bodies.
DCUN1D2 and NEDD8 are enriched in the PNS paranodal region.
(20) Therefore, the localization of NEDD8 in the myelinated fibers was examined by double immunostaining using specific antibodies against NEDD8 and MAG.
DCUN1D2 and NEDD8 are present in non-myelinating Schwann cells.
Accumulation of DCUN1D2 and NEDD8 at the myelin paranodes is influenced by fiber diameter.
NEDD8 staining patterns showed similar results (Fig.
NEDD8 also appeared at the paranodal regions at P21, which was similar to DCUN1D2 (data not shown).
Disruption of the paranodal axo-glial junction affects localization of DCUN1D2 and NEDD8. Since paranodal axo-glial junctions are formed relatively late during myelination, we examined the influence of these junctions on the distribution of the neddylation-related molecules.