NDM-1

NDM-1

New Dehli metallo-beta-lactamase 1. A recently-identified gene mutation which is responsible for a new class of drug-resistant superbacteria (”superbugs”). First isolated from medical tourists who had returned to Great Britain after having plastic surgery in India or Pakistan, the NDM-1 mutation has been identified in bacteria (e.g., Klebsiella pneumoniae and E. coli) in patients in Australia, Britain, Canada and the US, and has been associated with urinary tract infections, bacteraemia and pneumonia. It is resistant to virtually all antibiotics.
References in periodicals archive ?
Carbapenem group of antibiotics is one of the most effective drugs that has been used as a last remedy for the treatment of infections caused by Multi Drug Resistant (MDR) Gram negative bacilli.1 To neutralize the drugs, such NDM-1 producing bacteria encode various carbapenemases which are [beta]-lactamases, having the ability to hydrolyze majority of [beta]-lactams including carbapenems.2 Irrational use of antimicrobials give birth to resistance by increasing selective pressure in the bacterial population.
An example is NDM-1, which is a protein that can confer resistance in a range of bacteria.
Gram negative bacteria are today's major worldwide health concern because of production hydrolytic enzyme New Delhi Metallo-[beta]-lactamase (NDM-1).
The VIMs (VIM-1, 4, 5, 23, and 31; n = 51 [46 were only positive for VIM, and 5 co-produced OXA-48]) were the most common carbapenemase among this collection, followed by NDMs (NDM-1, 6, and 7; n = 43 [41 were positive only for NDM, 1 also co-produced OXA-48.
Reportedly, this key research programme is aimed at tackling the threat posed by NDM-1 and other metallo-[sz]-lactamases, enzymes that make bacteria resistant to widely used beta-lactam antibiotics such as penicillin.
HYPE-WIPE bleach towelettes are EPA registered in all states as a one-step disinfectant with a one- minute kill time forTB, Streptococcus, Salmonella, Pseudomonas, Norovirus, RSV, H1N1, ESBL, CRKP and Rotavirus, Hepatitis B, Hepatitis C, Enterobacter cloacae NDM-1, Escherichia coli NDM-1, Klebsiella pneumoniae NDM-1, MDR Enterococcus faecium, MDR Staphylococcus aureus, VRSA; two-minute kill time for MRSA, VRE, Staph; and a four-minute kill time for C.
Distribution of Carbapenem Resistant genes among Gram Negative Bacteria isolated from Urinary tract Infection in patients with type 2 diabetes mellitus Isolates [bla.sub.IMP] [bla.sub.VIM] IMP-1 IMP-8 VIM-1 VIM-24 E.coli 3 1 -- 1 Klebsiella pneumoniae -- 1 -- 1 Citrobacter freundii 1 -- 1 1 Acinetobacter baumanii 1 -- 1 -- Proteus mirabilis -- -- -- -- Enterobacter cloacae -- -- -- -- Isolates [bla.sub.NDM] [bla.sub.SPM-1] NDM-1 NDM-2 NDM-4 E.coli 4 1 2 -- Klebsiella pneumoniae 3 1 -- 2 Citrobacter freundii 2 2 1 -- Acinetobacter baumanii 2 3 -- -- Proteus mirabilis 1 -- -- -- Enterobacter cloacae -- -- -- --
La emergencia en 2007 de la carbapenemasa descrita mas recientemente, denominada New Delhi Metalo-[beta]-lactamasa 1 (NDM-1), constituye un problema medico critico, ya que esta enzima compromete la eficacia de casi todos los antibioticos [beta]-lactamicos y desde entonces, los CPO productores de NDM han sido identificados alrededor del mundo y descritos como endemicos en India, la peninsula de Balkan y el medio oriente (1).
Among all CPE, the most common enzyme was NDM-1. [3] NDM-1 was first described in 2008 in a Swedish patient returning from New Delhi, India, [8] in both Escherichia coli and K.
Keywords: Carbapenem-resistant enterobacteriaceae, Superbugs, NDM-1, Metallobetalactamase.