NCOA2

NCOA2

A gene on chromosome 8q13.3 that encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors, which are conditional transcription factors that play important roles in cell growth, development and homeostasis by controlling expression of specific genes.
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Partial sequencing of the TOX and NCOA2 genes in buffaloes.
Among the dysregulated genes, the top 12 genes from All Sources, Blood Source, Lymphocyte Source, and Monocyte Source were CDC37, NCOA2, P2RY12, RXRB, EDEM2, ACTN4, STX12, PPM1A, PRKACB, DUSP10, VEGFA, and SLC44A2.
Other genetic alterations include the NCOA2 gene fusion, which is common in congenital cases, and the MYOD1 gene mutation, which tends to occur in older children and adults.
The AR abnormality is the most mentioned one in bibliography because it can modulate NCOA2, NCOR2, and regulatory elements like FOXA1 [16, 19-21].
The strongest effect of Q(10) H(2) incubation was found for the nuclear receptor coactivator 2 gene (NCOA2).
Likewise, prostaglandin G/H synthase 2 (PTGS2, degree = 15) displayed the most affinitive connections with compounds, followed by prostaglandin G/H synthase 1 (PTGS1, degree = 13) and nuclear receptor coactivator 2 (NCOA2, degree = 11).
Assessing DNA copy number, messenger RNA expression, and focused exon resequencing in 218 prostate cancer tumors, the authors identified the role of nuclear receptor coactivator NCOA2 as a novel oncogene in 11% of PCa cases.
RARB is assumed to modify the expression levels of four genes: ELF3, NCOA2, ZNF42, and CDKN1A.
The only other linkage that did not appear to be supported by these data was the hypothesized linkage between NCOA2 and ZNF42.
Assessing DNA copy number, mRNA expression, and focused exon resequencing in 218 PCa tumors, the authors (74) identified the role of nuclear receptor coactivator NCOA2 as a novel oncogene in 11% of PCa cases.