NCOA1

NCOA1

A gene on chromosome 2p23 that encodes a protein of the p160/steroid receptor coactivator family, which acts as a transcriptional coactivator for steroid and nuclear hormone receptors, coactivating different nuclear receptors—e.g., PGR, GR and ER, retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors, and may participate in chromatin remodelling and recruitment of general transcription factors. NCOA1 acts with NCOA2 to control energy balance between white and brown adipose tissues.
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References in periodicals archive ?
Rhabdomyoblastic differentiation is particularly associated with alternate PAX3 fusion partners FOXO1 and NCOA1. (4-6,12) However, cases with the more common PAX3-MAML3 gene fusion have also been reported to express skeletal muscle markers myogenin and myoD1, so expression of these markers is not specific for alternate PAX3 fusion partners.
Wang et al, (3) 2014 (a) 25 19 Huang et al, (5) 2016 (a) 7 4 Wong et al, (4) 2016 1 1 Rooper et al, (11) 2016 (a) 11 6 Fritchie et al, (6) 2016 (a) 44 24 3 Source, y PAX3- PAX3-Unknown MAML3 NCOA1, No.
Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1. CancerRes.