NCK1

NCK1

A gene on chromosome 3q21 that encodes an adapter protein which associates with tyrosine-phosphorylated growth factor receptors (e.g., KDR and PDGFRB) or their substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. It plays a role in DNA damage response by activating downstream effectors, such as that of CHEK2, and in ELK1-dependent
transcriptional activation in response to activated Ras signalling.
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Different up-regulated proteins during the disease include insulin growth factor (IGF) II, a disintegrin and metalloproteases (ADAM) 9, signal transducers and activators of transcription (STAT) 3, suppressors of cytokine signalling (SOCS) 3, and cyclin D1 while the down-regulated proteins during the disease include collagen I, SMAD 4, fragile histidine triad (FHIT), and SOCS1.17 Other proteins include, POU class 5 homeobox 1 (OCT4), baculoviral IAP repeat containing 5 (BIRC5), cyclin D1 (CCND1), ATP binding cassette subfamily G member 2 (BCRP), SRY-box 2 (Sox2), Glutathione S-transferases (GST), NCK adaptor protein 1 (NCK1), human leukocyte antigen DQ (HLA-DQ), miR-106b, c-Myc, Ki67 and selective internal radiation therapy (SIRT).
Analysis of gene expression of cytoskeleton regulators indicated that short-term exposure of ASCs to 0.1% [O.sub.2] downregulated the expression of ACTR3, DSTN, MACF1, MIDI, MYPT1, NCK1, ROCK1, TIAM1, and WASF1, the products of which represent important regulators of [beta]-actin depolymerisation and lamellipodia formation.
Recruitment of dynamic complexes comprising NCK adaptor protein 1 (NCK1), RAS p21 protein activator 1 (p120GAP), and P21 protein-activated kinase 1 (PAK1), to TIE2 by the DOKs, especially DOK2, has been attributed to increased cell motility [35].