orthostatic intolerance

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orthostatic intolerance

A condition (OMIM:604715) characterised by lightheadedness, fatigue, altered mentation, syncope and tachycardia upon assuming an upright position, and markedly elevated serum norepinephrine. 

Molecular pathology
Defects in SLC6A2, which encodes a member of the sodium:neurotransmitter symporter that regulates norepinephrine homeostasis, are a cause of orthostatic intolerance.

or·tho·stat·ic in·tol·er·ance

(ōr'thō-stat'ik in-tol'ĕr-ăns)
Decreased venous return in the upright position typically experienced by astronauts after returning to an environment subject to gravity.

orthostatic intolerance

Loss of consciousness, near fainting, or light-headedness occurring when a person stands up from a seated or resting position. It is caused by insufficient blood flow to the brain, typically brought on by inability to raise blood pressure during changes in posture.
References in periodicals archive ?
5.Promote such patient advocates and other NCD material and media content through social media channels.
'During the PIR, local government units with best public heath practices currently being implemented will be presented to inspire other LGUs to adopt or initiate another innovation in promoting health care programs in their municipalities for the benefit of their constituents safeguarding their health against NCDs,' she emphasized.
This is to ensure that consumables that expose citizens to health dangers are restricted on the market, since they are known to be the major contributors to Non Communicable Diseases (NCDs), which contribute to 43 percent of all deaths in the country.
The objective of this study was to assess NCD service availability, readiness and utilization for prevention, screening, and treatment services across representative CHCs from rural provinces in northern Vietnam.
The discussion found that burden of Reproductive Mother Newborn and Child (RMNC) and communicable diseases has though gradually declined in the country, but the situation of NCDs is worrisome.
Under the leadership of Doctor Fred Amegashie (MoH) and Doctor Jason Beste (PIH), the Liberia Communicable Disease and Injury (NCDI) has worked throughout 2017 to gather information to show the country's NCD burden and intervention profile.
It should be noted in very categorical terms that NCD contributed immensely to the peace process in Sierra Leone with reference to the 'National Consultative Conference on the Peace Process in Sierra Leone'.
Specifically, the final NCD aligns with AMP's recommendations in two major ways:
The health department launched on Wednesday the NCD Mobile Phone Survey project which seeks to understand more about how Filipinos keep themselves healthy.
Over-simplifications must be avoided, but it is true that the main drivers of the NCD plaque include:bull Food containing too much fat, sugar and/or saltbull The consumption of tobacco and alcoholbull Lack of physical exercise andbull Stress, time pressure and lack of rest.If an NCD is managed well, patients normally do not suffer devastating consequences for a long time.
Professor John Chambers, a cardiovascular epidemiologist from Imperial College London, was present at the roundtable to share his expertise on international best practices in NCD management, and challenges faced globally.
Gaps and inadequacies in the system can be tackled through appropriate measures like development of knowledge, skills, system thinking and leadership to enable our system to respond to NCD challenges effectively and efficiently.