DUSP26

(redirected from NATA1)

DUSP26

A gene on chromosome 8p12 that encodes putative dual-specificity phosphatase 26, which inactivates MAPK1 and MAPK3, leading to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. DUSP26 inhibits MAP kinase p38/MAPK14 by dephosphorylating it and inhibiting p38-mediated apoptosis in anaplastic thyroid carcinoma; it also activates MAP kinases p38/MAPK14 and JNK/MAPK8. DUSP26 is also a less preferred gene symbol for what is now designated as DUSP28, see there.

Molecular pathology
DUSP26 is expressed in embryonal cancers (retinoblastoma, neuroepithelioma, neuroblastoma) and in anaplatic thyroid carcinoma
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References in periodicals archive ?
Among them, eight genes were involved in stress resistance, namely, genes encoding glucan endo-1,3-beta-glucosidase 11 (LCONS_000 34335 and PAU030933.1), the acetyltransferase NATA1 (LCONS_00013095), zinc finger CCCH domain-containing protein 9 (LCONS_00004917 and LCONS_00022081), disease-resistance protein (PAU018908.1), protein SRC2 (PAU030243.1), and cytochrome P450 (LCONS_00023050).
Jander, "Arabidopsis NATA1 acetylates putrescine and decreases defense-related hydrogen peroxide accumulation," Plant Physiology, vol.