The NASCIS and other smaller studies suggest an increased incidence of sepsis (bloodstream infection) and pneumonia in the MP-treatment groups.
These doubters claim NASCIS results showed little if any statistically significant benefits from high-dose MP, and modest benefits were only demonstrated in a patient subgroup when data was later micro-analyzed.
Shanker Nesathurai (Boston) said NASCIS did not convincingly demonstrate MP's benefits (J Trauma 1998; 45).
(Annapolis, Md.) strongly criticized NASCIS 2 and 3 for methodological weaknesses and the lack of data that could be critically reviewed by others (J Spinal Disord 2000; 1313]).
NASCIS II ve III alismalarda kullanilan dozlar hucresel glukokortikoid reseptorlerini sature edecek dozun ok zerinde oldugundan faydali etkinin antioksidan mekanizma veya iskemi veya dem alanlarinda yuksek doku duzeyine ulasmasi ile aiklanabilir.
John Hurlbert debated these findings by indicating that although the NASCIS were well-designed and -executed, they failed to demonstrate improvement in primary outcome measures as a result of methylprednisolone administration.