difficile testing on the identification of NAP1
, which is often used today as an indicator of disease severity.
Demonstration of an 18-base pair deletion of the tcd C gene, after amplification, indicated the presence of NAP1
difficile is a relatively recent phenomenon secondary to the emergence of the NAP1
and NAP2 compounds display exactly the same values as DAE, and the peaks of the higher viscosity naphthenics (NAP3 and NAP4) are positioned a couple of degrees higher.
Hyper virulent Clostridium difficile NAP1
is present in Nevada.
strain type predicts outcomes from Clostridium difficile infection.
Comparison of molecular characteristics of two Clostridium difficile isolates with historical standard-type strains and a recently recognized epidemic strain, by selected characteristics--Ohio and Pennsylvania, 2005 Strain Characteristic Standard Epidemic Ohio Pennsylvania Toxinotype 0 III IX XIV/XV PFGE * pattern <80% related NAP1
85% related 64% related to NAP1
([dagger]) Binary toxin - + + + 18-bp deletion in tcdC - + - + * Pulsed-field gel electrophoresis.
She reported the NAP1
strain, which produces more poisonous toxins than prior C-diff strains, does not respond well to Flagyl, and also raised concerns with use of Vancomycin that increases the prevalence of VRE.
difficile infections (CDI) is growing in many countries due in part to the dissemination of a hyper virulent strain known as North America Pulse type 1 (NAP1
) or ribotype 027.2
difficile epidemic in the early 2000s, when CIDT use was widespread for this infection and the emergence of the NAP1
strain was not detected until 5 years after steady increases in C.
difficile, the North American pulsed-field gel electrophoresis type 1 (NAP1
), which "is considered a major factor for the recent increase in adults," Dr.