IL8

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IL8

A gene on chromosome 4q13-q21 that encodes interleukin-8, a cytokine belonging to the CXC chemokine family. IL8 is a major mediator of inflammation, acting as a chemoattractant for neutrophils, basophils and T-cells, and is a potent angiogenic factor.

Molecular pathology
IL8 is a candidate gene for bronchiolitis.
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References in periodicals archive ?
difficile testing on the identification of NAP1, which is often used today as an indicator of disease severity.
Demonstration of an 18-base pair deletion of the tcd C gene, after amplification, indicated the presence of NAP1 strain.
difficile is a relatively recent phenomenon secondary to the emergence of the NAP1 strain.
The NAP1 and NAP2 compounds display exactly the same values as DAE, and the peaks of the higher viscosity naphthenics (NAP3 and NAP4) are positioned a couple of degrees higher.
Hyper virulent Clostridium difficile NAP1 is present in Nevada.
NAP1 strain type predicts outcomes from Clostridium difficile infection.
Comparison of molecular characteristics of two Clostridium difficile isolates with historical standard-type strains and a recently recognized epidemic strain, by selected characteristics--Ohio and Pennsylvania, 2005 Strain Characteristic Standard Epidemic Ohio Pennsylvania Toxinotype 0 III IX XIV/XV PFGE * pattern <80% related NAP1 85% related 64% related to NAP1 to NAP1 to NAP1 ([dagger]) Binary toxin - + + + 18-bp deletion in tcdC - + - + * Pulsed-field gel electrophoresis.
She reported the NAP1 strain, which produces more poisonous toxins than prior C-diff strains, does not respond well to Flagyl, and also raised concerns with use of Vancomycin that increases the prevalence of VRE.
difficile infections (CDI) is growing in many countries due in part to the dissemination of a hyper virulent strain known as North America Pulse type 1 (NAP1) or ribotype 027.2
difficile epidemic in the early 2000s, when CIDT use was widespread for this infection and the emergence of the NAP1 strain was not detected until 5 years after steady increases in C.
difficile, the North American pulsed-field gel electrophoresis type 1 (NAP1), which "is considered a major factor for the recent increase in adults," Dr.