NANOS1

NANOS1

A gene on chromosome 10q26.11 that encodes a protein thought to regulate translation of specific mRNAs by forming a complex with PUM2 at the 3'-UTR of mRNA targets. NANOS1 interacts with CTNNB1, CTNND1, PUM2 and SNAPIN; it interferes with the proadhesive and anti-invasive functions of E-cadherin, and is downregulated by E-cadherin. It is primarily expressed in the testes during germline development; in adults, it is expressed in spermatogonia, the male germline stem cells. It is also expressed in foetal ovaries and possibly also in premeiotic female germ cells.

Molecular pathology
NANOS1 upregulates the production of MMP14 to promote tumour cell invasion. It is highly expressed in lung cancer, especially in invasive tumour cells; its expression correlates with tumour aggressiveness.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
miRNA Target mRNA miR-122 CAT-1 miR-134 LIMK1 miR-19 RhoB miR-548c-3p TOP2A miR-430 Nanos1 and TDRD7 miR-221 and P27KIP1 miR-222 miR-19b PTEN miR-20a KRAS miR-166/165 Homeodomain leucine zipper transcript factor miR-184 and LRRK2 let-7 miR-26a/b IL-6 miR-485-5p BACE1 miR-145 OCT4, SOX2, and NANOG miRNA Expression regulation Reference miR-122 In response to amino acid starvation, [105,110] HuR binding to 3'UTR interferes with miRNP association with CAT-1 mRNA and results in relocalization of mRNP from P bodies in the cytoplasm to polysomes.