The available data suggests that HCV is a major cause of NANB hepatitis
throughout the world.
None of the patients with acute hepatitis A or B were HCV RNA positive, while HCV RNA was detected in 70 of 128 patients with acute NANB hepatitis
Hepatitis C (HCV) was previously known as NANB hepatitis
, and 80% to 90% of the viral hepatitis associated with blood transfusions used to be the most common mechanism for HCV transmission.
It proffered evidence that, according to the consensus of experts, ALT testing would not have detected approximately 70 percent of donors infected with the then-unknown viral agent HCV; that the same percentage of donors excluded on the basis of ALT testing would have annually excluded many thousands of units of healthy blood from donors not carrying hepatitis, while failing to detect the vast majority of donors carrying NANB hepatitis
. The patient conceded that he could not prove by greater than 50% (more likely than not) that he would not have been infected even if ALT testing had been performed.
: A new antibody test for the hepatitis C virus.
Particularly because IV-drug use is the most commonly identified risk factor reported by persons with NANB hepatitis[4,5], some of these patients may have had either acute or chronic NANB hepatitis of viral etiology in addition to lead poisoning.
During the outbreak, the OHD notified health-care providers that any NANB hepatitis case should be reviewed for possible lead poisoning.
For the past six years, because there is no effective treatment for NANB hepatitis, Griffith has suffered recurrent fevers, chills, hemorrhaging and abdominal pains.
Before blood banks started new NANB hepatitis screening tests in 1986, the chances of getting this disease ftom a transfusion were about one in ten.
Balayan isolated hepatitis E virus responsible for water-borne NANB hepatitis
and Houghton isolated hepatitis C virus causing blood-borne NANB hepatitis
In Wabash County, a small rural county in southern Illinois (estimated 1987 population: 13,800), only one other case of NANB hepatitis had been reported since 1982.
Of the 17 reported cases, 14 met a case definition for NANB hepatitis: an acute illness with symptoms and signs of hepatitis, elevated serum alanine aminotransferase (ALT) levels [is greater than] 2.5 times the upper limit of normal, and negative serologic markers for acute hepatitis A and B.