NALP3 inflammasome

NALP3 inflammasome

A well-characterised inflammasome (a multiprotein cytoplasmic complex which activates one or more caspases, leading to the processing and secretion of pro-inflammatory cytokines—e.g., IL-1 beta, IL-18 and IL-33) composed of NALP3, ASC, pro-caspase-1, and Cardinal. Assembly of inflammasomes depends on the NOD-like receptor family members, such as the NALP proteins.
References in periodicals archive ?
Halle et al., "Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization," Nature Immunology, vol.
Lauber et al., "Sodium overload and water influx activate the NALP3 inflammasome," Journal of Biological Chemistry, vol.
A gain-of-function mutation in NLRP3 (CIAS1), which encodes the NALP3 inflammasome leading to overproduction of IL-1, has been described in four patients with SchS [12, 13].
Tschopp, "Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration," Cell Death & Differentiation, vol.
The inflammatory cascade initiated within the macrophage involves both asbestos-induced NALP3 inflammasome activation and ROS-induced TNF[alpha] and NF-[kappa]B signaling.
NLRP[3.sup.-/-] or Caspase-[1.sup.-/-] mice showed reduced brain Caspase-1 and IL-1[beta] activation, protected spatial memory, and enhanced A[beta] clearance [31], indicating that the activation of the NALP3 inflammasome by A[beta] may be a critical component of the inflammatory response in AD.
Previous study has found that high extracellular potassium concentration (130 mM) can block the activation of NALP3 inflammasome and inhibit the activation ofcaspase-1.
Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature.
Expression and regulation of the NALP3 inflammasome complex in periodontal diseases.