This protein is part of the NALP3 inflammasome
Sodium overload and water influx activate the NALP3 inflammasome
. J Biol Chem 2011;286:35-41.
Halle et al., "Silica crystals and aluminum salts activate the NALP3 inflammasome
through phagosomal destabilization," Nature Immunology, vol.
Lauber et al., "Sodium overload and water influx activate the NALP3 inflammasome
," Journal of Biological Chemistry, vol.
A gain-of-function mutation in NLRP3 (CIAS1), which encodes the NALP3 inflammasome
leading to overproduction of IL-1, has been described in four patients with SchS [12, 13].
Tschopp, "Activation of the NALP3 inflammasome
is triggered by low intracellular potassium concentration," Cell Death & Differentiation, vol.
The inflammatory cascade initiated within the macrophage involves both asbestos-induced NALP3 inflammasome
activation and ROS-induced TNF[alpha] and NF-[kappa]B signaling.
NLRP[3.sup.-/-] or Caspase-[1.sup.-/-] mice showed reduced brain Caspase-1 and IL-1[beta] activation, protected spatial memory, and enhanced A[beta] clearance , indicating that the activation of the NALP3 inflammasome
by A[beta] may be a critical component of the inflammatory response in AD.
Previous study has found that high extracellular potassium concentration (130 mM) can block the activation of NALP3 inflammasome
and inhibit the activation ofcaspase-1.
Innate immune activation through Nalp3 inflammasome
sensing of asbestos and silica.
Gout-associated uric acid crystals activate the NALP3 inflammasome
Expression and regulation of the NALP3 inflammasome
complex in periodontal diseases.