Inflammation such as this is a feature of the human autosomal recessive disease mevalonate kinase deficiency, caused by NALP3
inflammasome-mediated IL1[beta] secretion .
Activation of NALP3
inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia.
forms an IL-1 [beta]processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
After 2hr infection there was reduced co-localization of NALP3
, ASC, and, caspase 1 in IL-10KO DCs.
forms an IL-1[beta]-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder," Immunity, vol.
inflammasome activation can be induced by potassium ([K.sup.+]) efflux .
The production of proinflammatory cytokines required two signalling pathways to be active, one initiated by the protein Tlr9 and one activated by a protein complex known as the Nalp3
Studies have shown that gout-associated uric acid crystals activate the NALP3
(cryopyrin) inflammasome, resulting in the production of active interleukin1 (IL-1).
Mazzon, "Human periodontal ligament stem cells secretome from multiple sclerosis patients suppresses NALP3
inflammasome activation in experimental autoimmune encephalomyelitis," International Journal of Immunopathology and Pharmacology, vol.
Bergstralh et al., "NLRP3 (NALP3
, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways," The Journal of Immunology, vol.
The inflammatory cascade initiated within the macrophage involves both asbestos-induced NALP3
inflammasome activation and ROS-induced TNF[alpha] and NF-[kappa]B signaling.