NLRP3

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NLRP3

A gene located on chromosome 1q44 that encodes a pyrin-like protein that interacts with the apoptosis-associated speck-like protein PYCARD/ASC. NLRP3 has a caspase recruitment domain, and belongs to the NALP3 inflammasome complex; it plays a role in regulating inflammation and apoptosis.
 
Molecular pathology
NLRP3 mutations are associated with chronic infantile neurological cutaneous and articular (CINCA) syndrome, familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome and neonatal-onset multisystem inflammatory disease (NOMID).
References in periodicals archive ?
Inflammation such as this is a feature of the human autosomal recessive disease mevalonate kinase deficiency, caused by NALP3 inflammasome-mediated IL1[beta] secretion [8].
Activation of NALP3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia.
NALP3 forms an IL-1 [beta]processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
After 2hr infection there was reduced co-localization of NALP3, ASC, and, caspase 1 in IL-10KO DCs.
Tschopp, "NALP3 forms an IL-1[beta]-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder," Immunity, vol.
NALP3 inflammasome activation can be induced by potassium ([K.sup.+]) efflux [103].
The production of proinflammatory cytokines required two signalling pathways to be active, one initiated by the protein Tlr9 and one activated by a protein complex known as the Nalp3 inflammasome.
Studies have shown that gout-associated uric acid crystals activate the NALP3 (cryopyrin) inflammasome, resulting in the production of active interleukin1 (IL-1).
Mazzon, "Human periodontal ligament stem cells secretome from multiple sclerosis patients suppresses NALP3 inflammasome activation in experimental autoimmune encephalomyelitis," International Journal of Immunopathology and Pharmacology, vol.
Bergstralh et al., "NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways," The Journal of Immunology, vol.
The inflammatory cascade initiated within the macrophage involves both asbestos-induced NALP3 inflammasome activation and ROS-induced TNF[alpha] and NF-[kappa]B signaling.