NALP1 inflammasome

NALP1 inflammasome

A well-characterised inflammasome (a multiprotein cytoplasmic complex which activates one or more caspases, leading to the processing and secretion of pro-inflammatory cytokines—e.g., IL-1 beta, IL-18 and IL-33) composed of NALP1, the adaptor protein ASC and pro-caspase-1 and -5. Assembly of inflammasomes depends on the NOD-like receptor family members, such as the NALP proteins.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.