Statistics of the occurrence of NALD
have doubled in the past 20 years.
Abbreviations: CG: complementation group; CHO: Chinese hamster ovary; DHAP-ATase: dihydroxyacetonephosphate acyltransferase; DLP1: dynamin-like protein 1; IRD: infantile Refsum disease; NALD
: neonatal adrenoleukodystrophy; PBD: peroxisome biogenesis disorder; PMP: peroxisomal integral membrane protein; PTS: peroxisome-targeting signal; RCDP: rhizomelic chondrodysplasia punctata; ZS: Zellweger syndrome.
This increase in mitochondrial ROS production likely plays an important role in the development of insulin resistance and leads to the function decline in activity of the ETC seen in the later stages of NALD
. Mitochondrial functional decline leads to a mismatch between fatty acid beta-oxidation and oxidative phosphorylation leading to the accumulation of partially oxidized intermediates which further exacerbate insulin resistance and leads to the progression of NAFLD.
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Retrieved January 30, 2008, from National Adult Literacy Database (NALD
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