methionine synthase

me·thi·o·nine syn·thase

tetrahydropteroylglutamate methyltransferase; methionine-homocysteine methyltransferase; an enzyme that catalyzes the reaction of N⁵-methyltetrahydrofolate with l-homocysteine to form tetrahydrofolate and l-methionine; a cobalamin-requiring enzyme; a deficiency of this enzyme results in an accumulation of l-homocysteine and neurological abnormalities.

Synonym(s): tetrahydrofolate methyltransferase

methionine synthase

(1) 5-Methyltetrahydrofolate-homocysteine S-methyltransferase, EC 2.1.1.13.
(2) O-Acetylhomoserine (thiol)-lyase, EC 4.2.99.10.