Furthermore, MoBiTec offers vectors encoding C- or N-terminal
His-tags for easy purification.
Also after 16 weeks with macitentan in comparison to placebo, a decrease by 20% was observed in the levels of N-terminal
pro b-type natriuretic peptide, which was the exploratory biomarker endpoint of the trial and also an indicator of cardiac response.
pro-brain natriuretic peptide (NT-proBNP) decreased by 970 pg/mL (p=0.
After the binding to one of these receptors PA undergoes a proteolytical processing by the furine class membrane protease which removes PA N-terminal
20 kDa domain (domain I, PA20).
Objective: To investigate the role of N-terminal
pro-brain natriuretic peptide and apelin in the assessment of right ventricular dysfunction in acute pulmonary embolism.
The first 5,000 enrollees also had measurements taken of their serum levels of N-terminal
probrain natriuretic peptide and cardiac troponin I through use of a high-sensitivity assay.
Objective: To analyze the effects of glutamine and valsartan on the brain natriuretic peptide (BNP) and N-terminal
pro-B-type natriuretic peptide (NT-proBNP) of patients with chronic heart failure (CHF).
Messersmith, Hu, and Su developed biocompatible macromonomer hydrogels using a thioester that readily reacts with an N-terminal
thiol (cysteine) through transesterification and rearrangement to form an amide bond through a five-member ring intermediate.
The primary study endpoint was change in N-terminal
of the prohormone brain natriuretic hormone (NT-proBNP), a biomarker of left ventricular wall stress, through 12 weeks.
These insights led the authors to propose a new "lock and trigger" model for spider silk formation, in which gradual pairing up of the N-terminal
domains locks spidroins into a network of many protein molecules, while the changes of structure in the C-terminal domains could trigger the rapid polymerization of spidroins into fibers.
The authors also found that while N-terminal
domain tended to pair up with other molecules at the beginning of the duct and became increasingly stable as the acidity increased along the duct, the other end the C-terminal domain destabilized as the acidity increased, and gradually unfolded until it formed the structure characteristic of silk at the acidic pH of 5.
The 15 N-terminal
amino acid sequences had some resemblance to those other of protease inhibitors and inhibitor precursors from leguminous plants.