What makes processed meats so ideal for forming N-nitroso
compounds is that they have a combination of nitrite and proteins from the meat.
Feron, and et al, "Nitrate, nitrite and N-nitroso
compounds," European Journal of Pharmacology, vol.
This endogenously formed nitrite, along with nitrite from dietary and drinking-water sources, can react with nitrosatable compounds such as amine- and amide-containing drugs to form N-nitroso
compounds in the stomach (Gillatt et al.
The study suggested that the iron in red meat, which is found in blood (heme iron) is thought to combine with protein and nitrates in food to create N-nitroso
, a carcinogen, in the gastrointestinal tract.
But a new study has refuted the role of hot dog-derived N-nitroso
compounds in colon cancer.
It is useful to recall that nitrate is a precursor in the body's formation of N-nitroso
compounds, which are potent carcinogens.
En la decada de los anos 60, y debido al descubrimiento de la formacion de la N-nitrosodimetilamina (NDMA) y de sus efectos cancerigenos (Magee y Barnes, 1956), se abrio un nuevo campo de investigacion sobre la actividad biologica de un gran numero de compuestos N-nitroso
Intake of nitrate from drinking water and dietary sources may cause increased exposure to N-nitroso
compounds through endogenous nitrosation (Mirvish, 1995).
Several processes are associated with meat and cancer: Meat is a source of carcinogens (compounds that can cause cancer) formed during high-temperature cooking as well as a source of N-nitroso
compounds--found in food products treated with nitrite.
Processing can produce several cancer-causing substances including N-nitroso
compounds, which are the product of nitrates, a common preservative in processed meat.
compounds (NOCs) found in some processed meat products and produced endogenously in the gut, are another class of carcinogens.
Ejemplo de esto es que, a un mismo valor de pH, la piperazina (pka 6, 74) forma un compuesto N-nitroso
a una velocidad 5x[10.