NMDA receptor

(redirected from N-methyl-D-aspartate receptor)
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NMDA re·cep·tor

a type of glutamate receptor that participates in excitatory neurotransmission and also binds N-methyl-d-aspartate; may be particularly involved in the cell damage observed in individuals with Huntington disease.

NMDA receptor

A brain receptor activated by glutamate, which when excessively stimulated may cause cognitive defects in Alzheimer's disease.
References in periodicals archive ?
Pillai et al., "Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-methyl-D-aspartate receptor or dopamine-2 receptor," Movement Disorders, vol.
Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.
N-Methyl-D-Aspartate receptor subunit NR2B is widely expressed throughout the rat diencephalon: an inmunohistochemical study.
Detection of the N-Methyl-D-Aspartate Receptor Subunit-1 (NMDAR-1) in the Hypothalamus of the Sheep by Western Blot Analysis.
The remaining chapters address such topics as age-associated memory impairment, cognition in Alzheimer's disease and related disorders, cognitive deficits as a core feature of schizophrenia, cognition in depression and mania, linking pre-clinical and clinical approaches to therapy for cognitive dysfunction in neuropsychiatric and neurodegenerative disorders, modulation of n-methyl-d-aspartate receptor function as a novel approach for development of antipsychotic agents, mechanisms of plasticity in molecular and cellular cognition, and functional imaging of cognition related brain circuitry in health and schizophrenia.
Ketamine, which directly targets the N-methyl-D-aspartate receptor complex, is known to produce adverse effects at higher doses or when used for a prolonged time, so it is unlikely to be used widely in clinical settings.
Keywords: Magnesium; Danshen; N-methyl-D-aspartate receptor; Patch clamp; Traditional Chinese medicine
DXM acts on the same receptor as phencyclidine (PCP), the N-methyl-D-aspartate receptor. Its affinity is about the same as ketamine, but not as high as PCP.
In 1999, a Princeton University team removed a gene associated with the N-methyl-D-aspartate receptor in the hippocampus, a component of the brain that is a critical tool in transforming short-term memories into long-term ones.
Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat.
CTP-692 is a deuterated form of D-serine, an endogenous co-agonist of the N-methyl-D-aspartate receptor, which has been demonstrated to be important to mood, memory, and cognition.

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