Then, 5-HT is transformed to N-acetylserotonin by arylalkylamine-N-acetyltransferase (AANAT).
TNF[alpha] inhibits AANAT mRNA expression as well as the synthesis of the melatonin precursor N-acetylserotonin .
The first leads to the formation of N-acetylserotonin and then to melatonin.
GABA enhanced the catabolism of serotonin to N-acetylserotonin, a precursor to melatonin in rats.
The Influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophan and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar Rat.
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Melatonin and N-acetylserotonin
are indoleamines synthesized in the pineal gland [60, 61], retina, and other tissues.
Melatonin's immediate precursor, N-acetylserotonin
, was not previously thought to have effects separate from those of melatonin or serotonin.Now Scientists at Emory University School of Medicine have shown that N-acetylserotonin
can stimulate the same circuits in the brain activated by the growth factor BDNF (brain-derived neurotrophic factor).The team was led by Keqiang Ye, associate professor of pathology and laboratory medicine, and P.