N-acetylserotonin


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N-acetylserotonin

A natural chemical intermediate in the production of melatonin from serotonin, and is produced by aralkylamine N-acetyltransferase (AANAT) and is converted to melatonin by acetylserotonin O-methyltransferase (ASMT). It acts as neurotransmitter at melatonin receptors MT1, MT2 and MT3. NAS’s distribution suggests that it may not be limited in its role as a melatonin precursor.
References in periodicals archive ?
Then, 5-HT is transformed to N-acetylserotonin by arylalkylamine-N-acetyltransferase (AANAT).
TNF[alpha] inhibits AANAT mRNA expression as well as the synthesis of the melatonin precursor N-acetylserotonin [14].
The first leads to the formation of N-acetylserotonin and then to melatonin.
GABA enhanced the catabolism of serotonin to N-acetylserotonin, a precursor to melatonin in rats.
The Influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophan and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar Rat.
Oxenkrug, "Antioxidant effects of N-acetylserotonin: possible mechanisms and clinical implications," Annals of the New York Academy of Sciences, vol.
Morton, "Scotophobin A causes dark avoidance in goldfish by elevating pineal N-acetylserotonin," Pharmacology Biochemistry and Behavior, vol.
Grota, "Analgesia induced by N-acetylserotonin in the central nervous system," Life Sciences, vol.
Pradoldej et al., "N-acetylserotonin activates TrkB receptor in a circadian rhythm," Proceedings of the National Academy of Sciences of the United States of America, vol.
Bachurin, "Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models," Annals of the New York Academy of Sciences, vol.
Melatonin and N-acetylserotonin are indoleamines synthesized in the pineal gland [60, 61], retina, and other tissues.
Melatonin's immediate precursor, N-acetylserotonin, was not previously thought to have effects separate from those of melatonin or serotonin.Now Scientists at Emory University School of Medicine have shown that N-acetylserotonin can stimulate the same circuits in the brain activated by the growth factor BDNF (brain-derived neurotrophic factor).The team was led by Keqiang Ye, associate professor of pathology and laboratory medicine, and P.
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