GALNS

(redirected from N-acetylgalactosamine-6-sulfatase)

GALNS

A gene on chromosome 16q24.3 that encodes N-acetylgalactosamine-6-sulfatase, a lysosomal exohydrolase required for the degradation of glycosaminoglycans, keratan sulfate and chondroitin 6-sulfate.

Molecular pathology
Defects of GALNS cause Morquio A syndrome, a lysosomal storage disease.
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References in periodicals archive ?
Recombinant Enzyme to Replace N-Acetylgalactosamine-6-Sulfatase for Mucopolysaccharidosis Type IIID - Drug Profile 50
These were combined with previously reported assays for mucopolysacharidoses (MPSs) [[alpha]-iduronidase (IDUA) for MPS-I, iduronate-2-sulfatase (I2S) for MPS-II, N-acetylgalactosamine-6-sulfatase (GALNS) for MPS-IVA, and N-acetylgalactosamine-4-sulfatase (ARSB) for MPS-VI] (8).
The disease is characterised by deficient activity of N-acetylgalactosamine-6-sulfatase (GALNS) causing excessive lysosomal storage of glycosaminoglycans such as keratan sulfate and chondroitin sulfate.

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